Plasma concentrations of brain natriuretic peptide in patients with acute ischemic stroke

被引:90
|
作者
Nakagawa, K
Yamaguchi, T
Seida, M
Yamada, S
Imae, S
Tanaka, Y
Yamamoto, K
Ohno, K
机构
[1] Tokyo Metropolitan Toshima Hosp, Dept Neurosurg, Itabashi Ku, Tokyo 1750013, Japan
[2] Tokyo Metropolitan Toshima Hosp, Dept Internal Med, Tokyo 1750013, Japan
[3] Tokyo Med & Dent Univ, Dept Neurosurg, Tokyo, Japan
[4] Tokyo Metropolitan Inst Gerontol, Dept Cell Biol, Tokyo, Japan
关键词
atrial fibrillation; brain natriuretic peptide; cerebral infarction; hemodynamic regulation;
D O I
10.1159/000083249
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Acute blood pressure (BP) elevation and cardiac abnormalities are known to follow ischemic stroke. Brain natriuretic peptide (BNP), which is produced in response to such cardiovascular alterations, is expected to play a hemodynamic role. We measured plasma BNP concentrations in patients with cerebral infarction (Cl) to determine the implications of BNP in acute ischemic stroke. Methods: Eighty-eight patients with Cl, 59 with essential hypertension, 44 with spontaneous intracerebral hemorrhage, 22 with asymptomatic atrial fibrillation (Af), and 20 age- and sex-matched healthy volunteers were recruited in the study. Cl patients were divided into 2 subgroups either having Af (27 patients) or not (61 patients). BNP levels were repeatedly measured in 58 patients with Cl. BNP levels were compared between ischemic subgroups categorized by size of infarction. Correlation was investigated between BNP levels and hemodynamic parameters. Results: BNP levels in Cl patients were significantly higher, but they decreased in the subacute period. BNP levels in Cl patients without Af were correlated with mean arterial blood pressure (MAP) on admission or the degree of reduction in MAP at day 1, while in Cl patients with Af BNP levels showed negative correlation with MAP on admission. Follow-up serum sodium levels in Cl patients with Af were negatively correlated with BNP levels on admission. Conclusions: This study suggests the hemodynamic implications of BNP in acute ischemic patients. Copyright (C) 2005 S. Karger AG, Basel.
引用
收藏
页码:157 / 164
页数:8
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