Accelerated Photo-Induced Hydrophilicity Promotes Osseointegration: An Animal Study

被引：44

作者：

Jimbo, Ryo ^{[2
]}

Ono, Daisuke ^{[1
]}

Hirakawa, Yuko ^{[1
]}

Odatsu, Tetsurou ^{[1
]}

Tanaka, Tsunehiro ^{[1
]}

Sawase, Takashi ^{[1
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Div Appl Prosthodont, Nagasaki 8528588, Japan

[2] Nagasaki Univ, Grad Sch Biomed Sci, Div Regenerat Oral Surg, Nagasaki 8528588, Japan

来源：

CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH | 2011年 / 13卷 / 01期

基金：

日本学术振兴会;

关键词：

anatase TiO2; enhanced bone apposition; fluoride; osseointegration; photo-induced hydrophilicity; ORAL IMPLANT SURFACES; DENTAL IMPLANTS; PLASMA FIBRONECTIN; TITANIUM IMPLANTS; BONE APPOSITION; IN-VIVO; RESPONSES; BEHAVIOR;

D O I：

10.1111/j.1708-8208.2009.00179.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Background: In the previous in vitro study, fluoride-modified, anodized porous titanium was proven to have enhanced its photo-induced hydrophilicity, which induced the hyperactivation of initial cell response. Purpose: The purpose of the present study was to investigate in vivo bone apposition during the early stages of osseointegration in rabbit tibiae. Materials and Methods: Anodized porous titanium implants (TiU, TiUnite (R), Nobel Biocare AB, Goteborg, Sweden) were modified with 0.175 wt% ammonium hydrogen fluoride solution (NH4F-HF2). Twenty-four hours prior to the experiments, the surface-modified implants were ultraviolet-irradiated (modTiU). Blinded and unpackaged TiU implants were used as controls. Thereafter, the implants were placed in the rabbit tibial metaphyses and histomorphometrically analyzed at 2 and 6 weeks after insertion. Results: ModTiU demonstrated a significantly greater degree of bone-to-metal contact than TiU after 2 and 6 weeks of healing. Conclusion: The results proved that the enhanced photo-induced hydrophilicity of the NH4F-HF2-modified anodized implants promoted bone apposition during the early stages of osseointegration.

引用

页码：79 / 85

页数：7

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