The Structure of Human Interferon Lambda and What It Has Taught Us

被引：24

作者：

Gad, Hans Henrik ^{[1
]}

Hamming, Ole Jensen ^{[1
]}

Hartmann, Rune ^{[1
]}

机构：

[1] Aarhus Univ, Struct Biol Ctr, Dept Mol Biol, DK-8000 Aarhus C, Denmark

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2010年 / 30卷 / 08期

基金：

英国医学研究理事会;

关键词：

CRYSTAL-STRUCTURE; INTERLEUKIN-10; REVEALS; GENETIC-VARIATION; RECEPTOR; COMPLEX; CYTOKINE; GAMMA; IDENTIFICATION; SIGNALS; EXPRESSION;

D O I：

10.1089/jir.2010.0062

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Type III interferon (IFN) or IFN-lambda is a novel family of class II cytokines that induces antiviral activities both in vitro and in vivo through its own distinctive receptor complex. The recent crystal structure of human IFN-lambda 3 revealed a cytokine with structural similarity to the interleukin-10 family, despite functionally being an IFN. Here, we review the structure of IFN-lambda and its relation to the other members of the class II cytokines. Further, we analyze the structural differences between the tree human isoforms of IFN-lambda and relate this to the observed differences in potency.

引用

页码：565 / 571

页数：7

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