Synthesis and Characterization of Injectable Hydrogels Based on Star β-CD-g-poly (L-glutamic acid)

被引：2
|
作者：
Jian Yuhang [1 ]
Yan Shifeng [1 ]
Li Xing [1 ]
Huang Yanan [1 ]
Yin Jingbo [1 ]
机构：
[1] Shanghai Univ, Sch Mat Sci & Engn, Dept Polymer Mat, Shanghai 200444, Peoples R China
来源：
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2017年 / 38卷 / 08期
基金：
上海市自然科学基金; 中国国家自然科学基金;
关键词：
Injectable hydrogel; beta-Cyclodextrin; Poly (L-glutamic acid); Sustained drug; POLY(L-GLUTAMIC ACID); CROSS-LINKING; DELIVERY; CYCLODEXTRIN; RELEASE; CHITOSAN; DEGRADATION; COMPLEXES; CELLS;
D O I：
10.7503/cjcu20170008
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A Gadelle-Defaye method was used to synthesis per-6-amino beta-CD [beta-CD-(NH2)(7)]. Then, different molecular weighted star beta-CD-g-poly (L-glutamic acid) (beta-CD-g-PLGA-ADH) was synthesised via "grafting-from" method. The hydrogel precursors, beta-CD-g-PLGA-ADH and oxided alginate(ALG-CHO) were mixed to prepare beta-CD-g-PLGA/ALG hydrogel. The effect of solid content and molecular weight of beta-CD-g-PLGA on the properties of hydrogel was studied. Simvastatin (SIM) was used as a model drug, the drug loading and release behavior of beta-CD-g-PLGA/ALG hydrogel were researched. The introduction of beta-CD into hydrogel made it an effective SIM loading and sustained release system.
引用
收藏
页码：1489 / 1496
页数：8
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