Preparation of redispersible dry emulsions by spray drying

被引:106
作者
Christensen, KL
Pedersen, GP
Kristensen, HG
机构
[1] Royal Danish Sch Pharm, Dept Pharmaceut, DK-2100 Copenhagen O, Denmark
[2] LEO Pharmaceut Prod, DK-2750 Ballerup, Denmark
关键词
spray drying; dry emulsion; lipid; hydroxypropylmethylcellulose (HPMC); microencapsulation; redispersibility;
D O I
10.1016/S0378-5173(00)00596-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Development of stable dry emulsions being able to reform the original o/w-emulsion by reconstitution in water is presented. Dry emulsions were prepared by spray drying liquid o/w-emulsions in a laboratory spray dryer. Three hydroxypropylmethylcellulose (HPMC) types were applied as solid carrier and emulsifier. The lipid phase was fractionated coconut oil. The ratio of solid carrier to lipid phase influenced the reconstitution properties. It was possible to prepare redispersible dry emulsions of a lipid content up to 40% dry powder mass. The different HPMC types had no noticeable effect on the reconstitution properties, but too viscous liquid o/w-emulsions were difficult to atomise. The type of rotary atomizer, or the rate of relation did not affect the technical properties of the dry emulsions containing 40% lipid. It was concluded that low viscosity HPMC was a useful solid carrier. The dry emulsions remained physically stable for at least 6 months. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
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页码:187 / 194
页数:8
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