Development of Near-Infrared Fluorescent Probes for Use in Alzheimers Disease Diagnosis

被引：62

作者：

Yang, Jian ^{[1
]}

Zeng, Fantian ^{[1
]}

Ge, Yiran ^{[1
]}

Peng, Kewen ^{[1
]}

Li, Xiaofang ^{[1
]}

Li, Yuyan ^{[2
]}

Xu, Yungen ^{[1
,2
]}

机构：

[1] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Dept Med Chem, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 21009, Peoples R China

来源：

BIOCONJUGATE CHEMISTRY | 2020年 / 31卷 / 01期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

BETA-AMYLOID AGGREGATION; IN-VIVO DETECTION; TAU FIBRILS; ANIMAL-MODELS; BODIPY DYES; PROTEIN-TAU; PLAQUES; INHIBITION; DESIGN; PHOTODEGRADATION;

D O I：

10.1021/acs.bioconjchem.9b00695

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder. Currently, there are no available treatments that can effectively stop or reverse the progression of the disease, and existing therapeutics can only alleviate the symptoms. Thus, it remains urgent to develop effective early-stage AD diagnostic methods. In recent years, the search for near-infrared fluorescent (NIRF) probes of AD hallmarks has become a promising research field. In this Review, we will focus on small-molecule NIRF probes used to detect beta-amyloid, tau proteins, and reactive oxygen species in vivo during the past 4 years. We believe that some new directions we raise herein will benefit the future development of NIRF probes in the field of AD research.

引用

页码：2 / 15

页数：14