Inactivation of SARS-CoV-2 in the Liquid Phase: Are Aqueous Hydrogen Peroxide and Sodium Percarbonate Efficient Decontamination Agents?

被引：27
作者：
Mileto, Davide [1 ]
Mancon, Alessandro [1 ]
Staurenghi, Federica [1 ]
Rizzo, Alberto [1 ]
Econdi, Stefano [2 ,3 ]
Gismondo, Maria Rita [1 ]
Guidotti, Matteo [2 ]
机构：
[1] Univ Hosp L Sacco, ASST Fatebenefratelli Sacco, Lab Clin Microbiol Virol & Bioemergency, I-20157 Milan, Italy
[2] Ist Sci & Tecnol Chim Giulio Natta, CNR SCITEC, I-20133 Milan, Italy
[3] Univ Milan, Dept Chem, I-20133 Milan, Italy
来源：
ACS CHEMICAL HEALTH & SAFETY | 2021年 / 28卷 / 04期
基金：
欧盟地平线“2020”;
关键词：
COVID-19; SARS-CoV-2; hydrogen peroxide; sodium percarbonate; biocidal agents; chemical inactivation; disinfection; virucidal solutions; COVID-19; ACID; CORONAVIRUSES; DISINFECTANTS; PERSISTENCE; EFFICACY; SURFACE; WATER;
D O I：
10.1021/acs.chas.0c00095
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
A diluted 3% w/w hydrogen peroxide solution acidified to pH 2.5 by adding citric acid inactivated SARS-CoV-2 virus by more than 4 orders of magnitude in 5 min. After a contact ti me of 15 min, no viral replication was detected. Aqueous solutions of sodium percarbonate inactivated coronavirus by >3 log(10) diminution in 15 min. Conversely, H2O2 solutions with no additives displayed a scarce virucidal activity (1.1 log(10) diminution in 5 min), confirming that a pH-modifying ingredient is necessary to have a H2O2 -based disinfectant active against the novel coronavirus.
引用
收藏
页码：260 / 267
页数：8
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