Multifunctional neuron-specific enolase: its role in lung diseases

被引：91

作者：

Xu, Cai-Ming ^{[1
,2
,3
]}

Luo, Ya-Lan ^{[1
,2
]}

Li, Shuai ^{[4
]}

Li, Zhao-Xia ^{[1
,2
]}

Jiang, Liu ^{[1
,2
]}

Zhang, Gui-Xin ^{[1
,2
]}

Owusu, Lawrence ^{[1
,2
,5
]}

Chen, Hai-Long ^{[1
,2
]}

机构：

[1] Dalian Med Univ, Affiliated Hosp 1, Dept Gen Surg, Dalian 116011, Liaoning, Peoples R China

[2] Dalian Med Univ, Inst Coll Intergrat Med, Dalian 116044, Liaoning, Peoples R China

[3] Dalian Obstet & Gynecol Hosp, Dept Tradit Chinese Med, Dalian 116021, Liaoning, Peoples R China

[4] Qingdao Women & Childrens Hosp, Dept Pediat Orthoped, Qingdao 266035, Shandong, Peoples R China

[5] Kwame Nkrumah Univ Sci & Technol KNUST, Dept Biochem & Biotechnol, Kumasi, Ghana

来源：

BIOSCIENCE REPORTS | 2019年 / 39卷

基金：

中国国家自然科学基金;

关键词：

GASTRIN-RELEASING PEPTIDE; C-TERMINAL PEPTIDE; GAMMA-ENOLASE; ALPHA-ENOLASE; TUMOR-MARKERS; CYFRA; 21-1; IMMUNORADIOMETRIC ASSAY; PROGNOSTIC-SIGNIFICANCE; PLASMINOGEN RECEPTOR; MONOCLONAL-ANTIBODY;

D O I：

10.1042/BSR20192732

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuron-specific enolase (NSE), also known as gamma (gamma) enolase or enolase-2 (Eno2), is a form of glycolytic enolase isozyme and is considered a multifunctional protein. NSE is mainly expressed in the cytoplasm of neurons and neuroendocrine cells, especially in those of the amine precursor uptake and decarboxylation (APUD) lineage such as pituitary, thyroid, pancreas, intestine and lung. In addition to its well-established glycolysis function in the cytoplasm, changes in cell localization and differential expression of NSE are also associated with several pathologies such as infection, inflammation, autoimmune diseases and cancer. This article mainly discusses the role and diagnostic potential of NSE in some lung diseases.

引用

页数：16

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