Implications of a polyglutamine tract in the function of the human androgen receptor

被引：55

作者：

Callewaert, L ^{[1
]}

Christiaens, V ^{[1
]}

Haelens, A ^{[1
]}

Verrijdt, G ^{[1
]}

Verhoeven, G ^{[1
]}

Claessens, F ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Fac Med, Div Biochem, B-3000 Louvain, Belgium

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 306卷 / 01期

关键词：

androgen receptor; CAG-repeat; polyglutamine; transcription; SUMO-1; ARE; direct repeat; coactivator;

D O I：

10.1016/S0006-291X(03)00902-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The androgen receptor (AR) is a ligand-dependent transcription factor and belongs to the nuclear receptor family. The AR gene contains a long polymorphic CAG repeat, coding for a polyglutamine tract. In the full size AR, the deletion of the polyglutamine tract results in an increase in the transactivation through canonical AREs. However, this effect is clearly dependent on the response elements, since it is not observed on selective elements. In our assays, a deletion of the repeat positively affected the interactions of the ligand-binding domain with the amino-terminal domain as well as the recruitment of the p160 coactivator SRC-1e to the amino-terminal domain of the AR. This is reflected by an enhanced coactivation of the AR by SRC-1e. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：46 / 52

页数：7

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