Advances and Biomedical Applications of Polypeptide Hydrogels Derived from α-Amino Acid N-Carboxyanhydride (NCA) Polymerizations

被引：72
|
作者：
Zhou, Xianfeng [1 ,2 ]
Li, Zhibo [1 ]
机构：
[1] Qingdao Univ Sci & Technol, Sch Polymer Sci & Engn, Shandong Prov Educ Dept, Key Lab Biobased Polymer Mat, Qingdao 266042, Peoples R China
[2] Univ Akron, Dept Polymer Sci, Akron, OH 44325 USA
来源：
ADVANCED HEALTHCARE MATERIALS | 2018年 / 7卷 / 15期
基金：
中国国家自然科学基金;
关键词：
amino acids; biomedical applications; NCAs; polypeptide hydrogels; supramolecular assembly; TEMPERATURE-SENSITIVE POLYPEPTIDE; SELF-ASSEMBLED HYDROGELS; MESENCHYMAL STEM-CELLS; SUPRAMOLECULAR HYDROGELS; HEPATOGENIC DIFFERENTIATION; RESPONSIVE HYDROGELS; BIOMIMETIC SCAFFOLDS; THERMAL GELATION; LOCAL-DELIVERY; 3D SCAFFOLD;
D O I：
10.1002/adhm.201800020
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Polypeptide hydrogels, having the ability to mimic certain properties of natural, native extracellular matrix components, are being actively designed and described for various applications in the construction of tissue engineering scaffolds, living cell encapsulation, and drug delivery systems. Compared to conventional hydrogels, polypeptide hydrogels possess biocompatibility, biodegradability, bioactivity, functional diversity, and structural advantage based on the unique secondary structures (alpha-helix and beta-sheet). Furthermore, the progresses in functional N-carboxyanhydride polymerization combined with advanced orthogonal conjugation techniques significantly promote the development of the polypeptide materials. This progress report focuses on the recent advances in designing and engineering polypeptide hydrogels obtained from ring opening polymerization, highlighting the precise manipulation of their properties for biomedical applications.
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页数：18
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