Synthesis, Molecular Docking Studies and Antifungal Activity Evaluation of New Thiazolyl-methylen-1,3,4-oxadiazolines as Potential Lanosterol 14α-demethylase Inhibitors

被引：0
|
作者：
Oniga, Smaranda [1 ]
Araniciu, Catalin [1 ]
Marc, Gabriel [2 ]
Uncu, Livia [3 ,4 ]
Palage, Mariana [1 ]
Oniga, Ovidiu [2 ]
机构：
[1] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Therapeut Chem, 12 Ion Creanga Str, Cluj Napoca 400010, Romania
[2] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Chem, 41 Victor Babes Str, Cluj Napoca 400012, Romania
[3] Nicolae Testemitanu State Univ Med & Pharm, Fac Pharm, Pharmaceut Chem & Toxicol, Kishinev, Moldova
[4] Nicolae Testemitanu State Univ Med & Pharm, Sci Ctr Drug Res, Kishinev, Moldova
来源：
REVISTA DE CHIMIE | 2019年 / 70卷 / 10期
关键词：
Thiazolyl-methylen-1,3,4-oxadiazolines; Candida albicans; lanosterol; 14; alpha-demethylase; DERIVATIVES; DESIGN; RESISTANCE; AGENTS;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Considering the well-established antifungal activity of azole compounds, a new series of thiazolyl-methylen-1,3,4-oxadiazolines derivatives were designed and synthesized as lanosterol-demethylase inhibitors. The final compounds were screened for antifungal activity against the Candida albicans ATCC 90028 strain. Molecular docking studies were performed to investigate the interaction modes between the compounds and the active site of lanosterol 14 alpha-demethylase, which is a target enzyme for anticandidal azoles. Theoretical ADME predictions were also calculated for the final compounds 5a-h.
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收藏
页码：3522 / 3526
页数：5
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