Neurological Aspects of Medical Use of Cannabidiol

被引:72
作者
Mannucci, Carmen [1 ]
Navarra, Michele [2 ]
Calapai, Fabrizio [1 ,3 ]
Spagnolo, Elvira V. [4 ]
Busardo, Francesco P. [5 ]
Cas, Roberto D. [6 ]
Ippolito, Francesca M. [6 ]
Calapai, Gioacchino [1 ,3 ]
机构
[1] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, Via Consolare Valeria 1, I-98125 Messina, Italy
[2] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Messina, Italy
[3] Ctr Studi Pharma Ca, Pharma Ca Res Facil, Messina, Italy
[4] Univ Palermo, Dept Biotechnol & Legal Med, Palermo, Italy
[5] Sapienza Univ Rome, Unit Forens Toxicol, Dept Anat Histol Forens & Orthoped Sci, Rome, Italy
[6] Natl Inst Hlth, Natl Ctr Epidemiol, Rome, Italy
关键词
Cannabidiol; neurodegenerative diseases; neurological; neurology; neuroprotection; IN-VIVO; MULTIPLE-SCLEROSIS; NEURODEGENERATIVE DISORDERS; PEDIATRIC EPILEPSY; PARKINSONS-DISEASE; RESISTANT EPILEPSY; ARTERY OCCLUSION; INDUCED TOXICITY; VANILLOID TRPV1; RAT MODEL;
D O I
10.2174/1871527316666170413114210
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Cannabidiol (CBD) is among the major secondary metabolites of Cannabis devoid of the delta-9-tetra-hydrocannabinol psychoactive effects. It is a resorcinol-based compound with a broad spectrum of potential therapeutic properties, including neuroprotective effects in numerous pathological conditions. CBD neuroprotection is due to its antioxidant and antiinflammatory activities and the modulation of a large number of brain biological targets (receptors, channels) involved in the development and maintenance of neurodegenerative diseases. Objective: The aim of the present review was to describe the state of art about the pre-clinical research, the potential use and, when existing, the clinical evidence related to CBD in the neurological field. Method: Collection of all the pre-clinical and clinical findings carried out investigating the effects of CBD alone, not in combination with other substances, in the neurological arena with the exclusion of studies on neuropsychiatric disorders. Results: Laboratory and clinical studies on the potential role of CBD in Parkinson's disease (PD), Alzheimer's disease (AD), multiple sclerosis (MS), Huntington's disease (HD), amyotrophic lateral sclerosis ALS), cerebral ischemia, were examined. Conclusion: Pre-clinical evidence largely shows that CBD can produce beneficial effects in AD, PD and MS patients, but its employment for these disorders needs further confirmation from well designed clinical studies. CBD pre-clinical demonstration of antiepileptic activity is supported by recent clinical studies in human epileptic subjects resistant to standard antiepileptic drugs showing its potential use in children and young adults affected by refractory epilepsy. Evidence for use of CBD in PD is still not supported by sufficient data whereas only a few studies including a small number of patients are available.
引用
收藏
页码:541 / 553
页数:13
相关论文
共 104 条
[21]   Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation [J].
Costa, B ;
Giagnoni, G ;
Franke, C ;
Trovato, AE ;
Colleoni, M .
BRITISH JOURNAL OF PHARMACOLOGY, 2004, 143 (02) :247-250
[22]   CHRONIC ADMINISTRATION OF CANNABIDIOL TO HEALTHY-VOLUNTEERS AND EPILEPTIC PATIENTS [J].
CUNHA, JM ;
CARLINI, EA ;
PEREIRA, AE ;
RAMOS, OL ;
PIMENTEL, C ;
GAGLIARDI, R ;
SANVITO, WL ;
LANDER, N ;
MECHOULAM, R .
PHARMACOLOGY, 1980, 21 (03) :175-185
[23]   Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes [J].
De Petrocellis, Luciano ;
Ligresti, Alessia ;
Moriello, Aniello Schiano ;
Allara, Marco ;
Bisogno, Tiziana ;
Petrosino, Stefania ;
Stott, Colin G. ;
Di Marzo, Vincenzo .
BRITISH JOURNAL OF PHARMACOLOGY, 2011, 163 (07) :1479-1494
[24]   Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour [J].
Deiana, Serena ;
Watanabe, Akihito ;
Yamasaki, Yuki ;
Amada, Naoki ;
Arthur, Marlene ;
Fleming, Shona ;
Woodcock, Hilary ;
Dorward, Patricia ;
Pigliacampo, Barbara ;
Close, Steve ;
Platt, Bettina ;
Riedel, Gernot .
PSYCHOPHARMACOLOGY, 2012, 219 (03) :859-873
[25]   Cannabidiol for epilepsy: trying to see through the haze [J].
Detyniecki, Kamil ;
Hirsch, Lawrence J. .
LANCET NEUROLOGY, 2016, 15 (03) :235-237
[26]   Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial [J].
Devinsky, Orrin ;
Marsh, Eric ;
Friedman, Daniel ;
Thiele, Elizabeth ;
Laux, Linda ;
Sullivan, Joseph ;
Miller, Ian ;
Flamini, Robert ;
Wilfong, Angus ;
Filloux, Francis ;
Wong, Matthew ;
Tilton, Nicole ;
Bruno, Patricia ;
Bluvstein, Judith ;
Hedlund, Julie ;
Kamens, Rebecca ;
Maclean, Jane ;
Nangia, Srishti ;
Singhal, Nilika Shah ;
Wilson, Carey A. ;
Patel, Anup ;
Cilio, Maria Roberta .
LANCET NEUROLOGY, 2016, 15 (03) :270-278
[27]   Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders [J].
Devinsky, Orrin ;
Cilio, Maria Roberta ;
Cross, Helen ;
Fernandez-Ruiz, Javier ;
French, Jacqueline ;
Hill, Charlotte ;
Katz, Russell ;
Di Marzo, Vincenzo ;
Jutras-Aswad, Didier ;
Notcutt, William George ;
Martinez-Orgado, Jose ;
Robson, Philip J. ;
Rohrback, Brian G. ;
Thiele, Elizabeth ;
Whalley, Benjamin ;
Friedman, Daniel .
EPILEPSIA, 2014, 55 (06) :791-802
[28]   Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression [J].
Esposito, G. ;
Scuderi, C. ;
Savani, C. ;
Steardo, L., Jr. ;
De Filippis, D. ;
Cottone, P. ;
Iuvone, T. ;
Cuomo, V. ;
Steardo, L. .
BRITISH JOURNAL OF PHARMACOLOGY, 2007, 151 (08) :1272-1279
[29]   Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in β-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-κB involvement [J].
Esposito, Giuseppe ;
De Filippis, Daniele ;
Maiuri, Maria Chiara ;
De Stefano, Daniela ;
Carnuccio, Rosa ;
Iuvone, Teresa .
NEUROSCIENCE LETTERS, 2006, 399 (1-2) :91-95
[30]   Cannabidiol Reduces Ab- Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement [J].
Esposito, Giuseppe ;
Scuderi, Caterina ;
Valenza, Marta ;
Togna, Giuseppina Ines ;
Latina, Valentina ;
De Filippis, Daniele ;
Cipriano, Mariateresa ;
Carratu, Maria Rosaria ;
Iuvone, Teresa ;
Steardo, Luca .
PLOS ONE, 2011, 6 (12)