Long-term use of pegylated liposomal doxorubicin to a cumulative dose of 4600mg/m2 in recurrent ovarian cancer

被引：12

作者：

Pendlebury, Adam ^{[1
]}

DeBernardo, Robert ^{[1
]}

Rose, Peter G. ^{[1
]}

机构：

[1] Cleveland Clin, Taussig Canc Ctr, 9500 Euclid Ave,A81, Cleveland, OH 44195 USA

来源：

ANTI-CANCER DRUGS | 2017年 / 28卷 / 07期

关键词：

cardiotoxicity; gynecologic malignancy; long-term chemotherapy; pegylated liposomal doxorubicin; safety; RANDOMIZED PHASE-III; EPITHELIAL OVARIAN; GYNECOLOGIC MALIGNANCIES; CARDIAC SURVEILLANCE; CARCINOMA; PLD; CARDIOTOXICITY; CHEMOTHERAPY; FAILURE; TRIAL;

D O I：

10.1097/CAD.0000000000000521

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pegylated liposomal doxorubicin (PLD) is used widely in gynecologic oncology and other oncology disciplines. Native doxorubicin use is associated with the potential for significant toxicity. Cardiac toxicity in particular limits lifetime dose. PLD has not been shown to be associated with clinical cardiac toxicity. We report on the long-term use of PLD in a patient with recurrent high-grade serous ovarian cancer to a lifetime dose of 4600mg/m(2). This therapy was associated with long-term stable disease, good performance status, and minimal adverse effects.

引用

页码：815 / 817

页数：3

共 20 条

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