Mesenchymal Stem Cell Transplantation Inhibits Abnormal Activation of Akt/GSK3β Signaling Pathway in T Cells from Systemic Lupus Erythematosus Mice

被引：35

作者：

Ji, Suyun ^{[1
]}

Guo, Qing ^{[1
]}

Han, Yanfang ^{[1
]}

Tan, Guozhen ^{[1
]}

Luo, Yijin ^{[1
]}

Zeng, Fanqin ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Dermatol, Guangzhou 510120, Guangdong, Peoples R China

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2012年 / 29卷 / 5-6期

基金：

中国国家自然科学基金;

关键词：

Systemic lupus erythematosus; Bone marrow mesenchymal stem cell; Transplantation; Cell cycle; Akt; GSK3; beta; MARROW STROMAL CELLS; BONE-MARROW; MRL/LPR MICE; PROLIFERATION; SURVIVAL; PROTEIN; AUTOIMMUNITY; DISTINCT; DISEASE; MODEL;

D O I：

10.1159/000178590

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by activation and proliferation of autoreactive T cells and B cells. We examined changes in cell cycle progression of T cells from MRL/lpr mice with or without allogenic bone marrow mesenchymal stem cells (BMMSCs) treatment and analyzed the expression of cell cycle associated proteins. In addition, the Akt/GSK3 beta protein kinase cascade was studied. We demonstrated that high-dose MSCs transplantation effectively ameliorated disease activity in MRL/lpr mice. BMMSCs treatment inhibited G1/S transition of the abnormal lupus T lymphocytes. Moreover, it increased the expression of p21(WAF1/CIP1) and p27(Kip1) and decreased the expression of CDK2. Furthermore, high-dose MSCs inhibited abnormal activation of the Akt/GSK3 beta signaling pathway of T cells from MRL/lpr mice. Our results suggest that high-dose BMMSCs transplantation successfully treated MRL/lpr lupus mice by inhibiting abnormal activation of Akt/GSK3 beta signaling pathway of T cells. Copyright (c) 2012 S. Karger AG, Basel

引用

页码：705 / 712

页数：8

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