Cell mediated and antibody immune response to inactivated hepatitis A vaccine

被引：34
作者：
Schmidtke, P
Habermehl, P
Knuf, M
Meyer, CU
Sänger, R
Zepp, F
机构：
[1] Johannes Gutenberg Univ Mainz, Childrens Hosp, D-55131 Mainz, Germany
[2] GlaxoSmithKline Inc, D-80339 Munich, Germany
来源：
VACCINE | 2005年 / 23卷 / 44期
关键词：
hepatitis A virus; vaccine; cellular immunity;
D O I：
10.1016/j.vaccine.2005.06.022
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The humoral and cellular immune response to inactivated hepatitis A vaccine was investigated dynamically in a time elapse study over 1 year. Fourty-five healthy volunteers, seronegative for anti-HAV, were vaccinated with 1440 enzyme-linked immunosorbent assay units (EU) of formalin-inactivated hepatitis A virus following a 0-6-month schedule. Serum anti-HAV levels and HAV-specific proliferation of peripheral blood mononuclear cells were measured at several time points over a 26- and 28-week period after the first and second injection, respectively. Distinct B and T cell responses were determined within 14 days after primary vaccination. The booster vaccination-induced immediate peak levels for the humoral (anti-HAV GMC = 5376 mIU/ml) as well as the cellular (median Delta cpm = 14173 cpm) response. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5127 / 5132
页数：6
相关论文
共 50 条
  • [41] Antibody Response to Influenza A(H1N1)pdm09 Among Healthcare Personnel Receiving Trivalent Inactivated Vaccine: Effect of Prior Monovalent Inactivated Vaccine
    Gaglani, Manjusha
    Spencer, Sarah
    Ball, Sarah
    Song, Juhee
    Naleway, Allison
    Henkle, Emily
    Bozeman, Sam
    Reynolds, Sue
    Sessions, Wendy
    Hancock, Kathy
    Thompson, Mark
    JOURNAL OF INFECTIOUS DISEASES, 2014, 209 (11) : 1705 - 1714
  • [42] Effects of Serum Selenium Level on Cell-Mediated Immunity and on Antibody Response to Multivalent Influenza Vaccine in Hemodialysis Patients
    Turkmen, Kultigin
    Ecder, Tevfik
    Turk, Sleyman
    TURKISH NEPHROLOGY DIALYSIS AND TRANSPLANTATION JOURNAL, 2012, 21 (01): : 84 - 88
  • [43] Immunogenicity of two versus three injections of inactivated hepatitis A vaccine in adults
    Chen, XQ
    Bulbul, M
    deGast, GC
    vanLoon, AM
    Nalin, DR
    vanHattum, J
    JOURNAL OF HEPATOLOGY, 1997, 26 (02) : 260 - 264
  • [44] Preparation of FMD type A87/IRN inactivated vaccine by gamma irradiation and the immune response on guinea pig
    Farahnaz Motamedi Sedeh
    Akbar Khorasani
    Kamal Shafaee
    Hadi Fatolahi
    Kourosh Arbabi
    Indian Journal of Microbiology, 2008, 48 : 326 - 330
  • [45] Immune Response to an Inactivated Vaccine of SARS-CoV-2 (CoronaVac) in an Indigenous Brazilian Population: A Cohort Study
    de Oliveira, Lais Albuquerque
    de Morais, Isa Rita Brito
    Barbosa, Marcelo dos Santos
    Marchioro, Silvana Beutinger
    Machado, Layla Oliveira Campos Leite
    Ferreira Marques, Michele
    Ferreira, Tiago da Silva
    de Almeida, Gabriel Barroso
    de Oliveira Barbosa, Dyjaene
    Torres, Alex Jose Leite
    Simionatto, Simone
    VACCINES, 2024, 12 (04)
  • [46] Preparation of FMD type A87/IRN inactivated vaccine by gamma irradiation and the immune response on guinea pig
    Sedeh, Farahnaz Motamedi
    Khorasani, Akbar
    Shafaee, Kamal
    Fatolahi, Hadi
    Arbabi, Kourosh
    INDIAN JOURNAL OF MICROBIOLOGY, 2008, 48 (03) : 326 - 330
  • [47] Antibody and cell-mediated immunity to Streptococcus pneumoniae: implications for vaccine development
    Richard Malley
    Journal of Molecular Medicine, 2010, 88 : 135 - 142
  • [48] Reduced T Cell and Antibody Responses to Inactivated Coronavirus Vaccine Among Individuals Above 55 Years Old
    Medeiros, Giuliana X.
    Sasahara, Greyce Luri
    Magawa, Jhosiene Y.
    Nunes, Joao Paulo S.
    Bruno, Fernanda R.
    Kuramoto, Andreia C.
    Almeida, Rafael R.
    Ferreira, Marcelo A.
    Scagion, Guilherme P.
    Candido, Erika D.
    Leal, Fabyano B.
    Oliveira, Danielle B. L.
    Durigon, Edison L.
    Silva, Roberto Carlos V., Jr.
    Rosa, Daniela S.
    Boscardin, Silvia B.
    Coelho, Veronica
    Kalil, Jorge
    Santos, Keity S.
    Cunha-Neto, Edecio
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [49] IMMUNE-RESPONSE TO HEPATITIS-B VACCINE IN PARENTERAL DRUG-ABUSERS
    RODRIGO, JM
    SERRA, MA
    APARISI, L
    ESCUDERO, A
    GILABERT, MS
    GARCIA, F
    GONZALEZ, R
    DELOLMO, JA
    WASSEL, AH
    ARTERO, A
    NOGUEIRA, JM
    VACCINE, 1992, 10 (11) : 798 - 801
  • [50] CHARACTERIZATION OF THE IMMUNE-RESPONSE OF VOLUNTEERS VACCINATED WITH A KILLED VACCINE AGAINST HEPATITIS-A
    DELEM, A
    SAFARY, A
    DENAMUR, F
    HAUSER, P
    DHONDT, E
    VACCINE, 1993, 11 (04) : 479 - 484
12345