Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species

被引：44

作者：

Uddin, MJ

Kokubo, S

Ueda, K

Suenaga, K

Uemura, D

机构：

[1] Univ Ryukyus, Dept Chem Biol & Marine Sci, Okinawa 9030213, Japan

[2] Nagoya Univ, Grad Sch Sci, Dept Chem, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 09期

关键词：

D O I：

10.1021/np010066n

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum, sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.

引用

页码：1169 / 1173

页数：5

共 18 条

[1]

BIRAD JF, 1994, NAT PROD LETT, V4, P43

[2] ASCIDIANS - PRODUCERS OF AMINO-ACID DERIVED METABOLITES [J].