Thyroid Hormone and the Cardiovascular System

被引：142

作者：

Danzi, Sara ^{[1
]}

Klein, Irwin ^{[1
]}

机构：

[1] CUNY Queensborough Community Coll, Dept Biol Sci & Geol, New York, NY 11364 USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2012年 / 96卷 / 02期

关键词：

Thyroid hormone; Cardiovascular system; Heart; Hemodynamics; AMIODARONE-INDUCED THYROTOXICOSIS; HEART-FAILURE; SARCOPLASMIC-RETICULUM; LOW-T-3; SYNDROME; GENE-EXPRESSION; HYPERTHYROIDISM; DISEASE; HYPOTHYROIDISM; PHOSPHOLAMBAN; CONTRACTILITY;

D O I：

10.1016/j.mcna.2012.01.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thyroid hormone has profound effects on the heart and cardiovascular system. This article describes the cellular mechanisms by which thyroid hormone acts at the level of the cardiac myocyte and the vascular smooth muscle cell to alter phenotype and physiology. Because it is well established that thyroid hormone, specifically T-3, acts on almost every cell and organ in the body, studies on the regulation of thyroid hormone transport into cardiac and vascular tissue have added clinical significance. The characteristic changes in cardiovascular hemodynamics and metabolism that accompany thyroid disease states can then be best understood at the cellular level.

引用

页码：257 / +

页数：13

共 60 条

[1]

[Anonymous], 2003, THYROID, V13, P3

[2] Thyroid hormone metabolism in patients with congestive heart failure: The low triiodothyronine state [J].

Ascheim, DD ;

Hryniewicz, K .

THYROID, 2002, 12 (06) :511-515

[3] HYPERTHYROIDISM AND OTHER CAUSES OF THYROTOXICOSIS: MANAGEMENT GUIDELINES OF THE AMERICAN THYROID ASSOCIATION AND AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS [J].

Bahn, Rebecca S. ;

Burch, Henry B. ;

Cooper, David S. ;

Garber, Jeffrey R. ;

Greenlee, Carol ;

Klein, Irwin ;

Laurberg, Peter ;

McDougall, I. Ross ;

Montori, Victor M. ;

Rivkees, Scott A. ;

Ross, Douglas S. ;

Sosa, Julie Ann ;

Stan, Marius N. .

ENDOCRINE PRACTICE, 2011, 17 (03) :456-520

[4] TIME COURSE OF THE INVIVO EFFECTS OF THYROID-HORMONE ON CARDIAC GENE-EXPRESSION [J].

BALKMAN, C ;

OJAMAA, K ;

KLEIN, I .

ENDOCRINOLOGY, 1992, 130 (04) :2001-2006

[5] Cardiac oxidative metabolism, function, and metabolic performance in mild hyperthyroidism:: A noninvasive study using positron emission tomography and magnetic resonance imaging [J].

Bengel, FM ;

Lehnert, J ;

Ibrahim, T ;

Klein, C ;

Bülow, HP ;

Nekolla, SG ;

Schwaiger, M .

THYROID, 2003, 13 (05) :471-477

[6] Hypothyroidism as a risk factor for cardiovascular disease [J].

Biondi, B ;

Klein, I .

ENDOCRINE, 2004, 24 (01) :1-13

[7] Effects of thyroid hormone on cardiac function: The relative importance of heart rate, loading conditions, and myocardial contractility in the regulation of cardiac performance in human hyperthyroidism [J].

Biondi, B ;

Palmieri, EA ;

Lombardi, G ;

Fazio, S .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (03) :968-974

[8] Overexpression of sarcoplasmic reticulum Ca2+-ATPase improves cardiac contractile function in hypothyroid mice [J].

Bluhm, WF ;

Meyer, M ;

Sayen, MR ;

Swanson, EA ;

Dillmann, WH .

CARDIOVASCULAR RESEARCH, 1999, 43 (02) :382-388

[9] Treatment of type II amiodarone-induced thyrotoxicosis by either iopanoic acid or glucocorticoids: A prospective, randomized study [J].

Bogazzi, F ;

Bartalena, L ;

Cosci, C ;

Brogioni, S ;

Dell'Unto, E ;

Grasso, L ;

Aghini-Lombardi, F ;

Rossi, G ;

Pinchera, A ;

Braverman, LE ;

Martino, E .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (05) :1999-2002

[10] Hypothyroidism and atherosclerosis [J].

Cappola, AR ;

Ladenson, PW .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (06) :2438-2444

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