DETECTION OF AGE-RELATED MACULAR DEGENERATION VIA DEEP LEARNING

被引:51
作者
Burlina, P. [1 ,2 ,3 ]
Freund, D. E. [1 ]
Joshi, N. [1 ]
Wolfson, Y. [3 ]
Bressler, N. M. [3 ]
机构
[1] Johns Hopkins Univ, Appl Phys Lab, Baltimore, MD 21218 USA
[2] Johns Hopkins Univ, Dept Comp Sci, Baltimore, MD 21218 USA
[3] Johns Hopkins Univ, Wilmer Eye Inst, Sch Med, Baltimore, MD 21218 USA
来源
2016 IEEE 13TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI) | 2016年
关键词
Age-related macular degeneration; deep learning; pre-trained networks; SUBGROUP ANALYSIS; RANIBIZUMAB; VERTEPORFIN;
D O I
10.1109/ISBI.2016.7493240
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Age-related macular generation (AMD) - when left untreated - is the main cause of blindness for individuals over the age of 50. With the US population now counting over 100 million individuals over 50, it is imperative to develop methods that can effectively determine which individuals with an earlier, often asymptomatic stage, are at risk of developing the advanced stage that can cause severe vision loss. This paper studies the appropriateness of the transfer of image features computed from pre-trained deep neural networks to the problem in AMD detection. Tests using over 5600 images from the NIH AREDS dataset (the largest dataset used thus far for AMD image analysis studies) show good preliminary results (between nearly 92% and 95% accuracy).
引用
收藏
页码:184 / 188
页数:5
相关论文
共 12 条
  • [1] Subgroup analysis of the MARINA study of ranibizumab in neovascular age-related macular degeneration
    Boyer, David S.
    Antoszyk, Andrew N.
    Awh, Carl C.
    Bhisitkul, Robert B.
    Shapiro, Howard
    Acharya, Nisha R.
    [J]. OPHTHALMOLOGY, 2007, 114 (02) : 246 - 252
  • [2] Bressler Neil M, 2004, JAMA, V291, P1900, DOI 10.1001/jama.291.15.1900
  • [3] Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    Brown, David M.
    Kaiser, Peter K.
    Michels, Mark
    Soubrane, Gisele
    Heier, Jeffrey S.
    Kim, Robert Y.
    Sy, Judy P.
    Schneider, Susan
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (14) : 1432 - 1444
  • [4] Ranibizumab versus Verteporfin Photodynamic Therapy for Neovascular Age-Related Macular Degeneration: Two-Year Results of the ANCHOR Study
    Brown, David M.
    Michels, Mark
    Kaiser, Peter K.
    Heier, Jeffrey S.
    Sy, Judy P.
    Ianchulev, Tsontcho
    [J]. OPHTHALMOLOGY, 2009, 116 (01) : 57 - 65
  • [5] Brown DM, 2009, OPHTHALMOLOGY, V116, pe55
  • [6] Burlina P, 2011, IEEE ENG MED BIO, P3962, DOI 10.1109/IEMBS.2011.6090984
  • [7] Automated segmentation of geographic atrophy of the retinal epithelium via random forests in AREDS color fundus images
    Feeny, Albert K.
    Tadarati, Mongkol
    Freund, David E.
    Bressler, Neil M.
    Burlina, Philippe
    [J]. COMPUTERS IN BIOLOGY AND MEDICINE, 2015, 65 : 124 - 136
  • [8] Freund DE, 2009, IEEE INT S BIOM IM N
  • [9] Ranibizumab for predominantly classic neovascular age-related macular degeneration: Subgroup analysis of first-year ANCHOR results
    Kaiser, Peter K.
    Brown, David M.
    Zhang, Kang
    Hudson, Henry L.
    Holz, Frank G.
    Shapiro, Howard
    Schneider, Susan
    Acharya, Nisha R.
    [J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 2007, 144 (06) : 850 - 857
  • [10] A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss - AREDS Report No. 8
    Kassoff, A
    Kassoff, J
    Buehler, J
    Eglow, M
    Kaufman, F
    Mehu, M
    Kieval, S
    Mairs, M
    Graig, B
    Quattrocchi, A
    Jones, D
    Locatelli, J
    Ruby, A
    Capone, A
    Garretson, B
    Hassan, T
    Trese, MT
    Williams, GA
    Regan, V
    Manatrey, P
    Streasick, P
    Szydlowski, L
    McIver, F
    Bridges, C
    Stanley, C
    Cumming, K
    Lewis, B
    Zajechowski, M
    Margherio, RR
    Cox, MS
    Camille, J
    Falk, R
    Siedlak, P
    Neubert, C
    Klein, ML
    Stout, JT
    O'Malley, A
    Lauer, AK
    Robertson, JE
    Wilson, DJ
    Beardsley, C
    Anderson, H
    Wallace, P
    Smith, G
    Howard, S
    Dreyer, RF
    Ma, C
    Chenoweth, RG
    Zilis, JD
    Johnson, M
    [J]. ARCHIVES OF OPHTHALMOLOGY, 2001, 119 (10) : 1417 - 1436