Mechanisms of pain

被引：93

作者：

Stucky, CL ^{[1
]}

Gold, MS

Zhang, X

机构：

[1] Med Coll Wisconsin, Dept Cell Biol Neurobiol & Anat, Milwaukee, WI 53226 USA

[2] Univ Maryland, Dept Oral & Craniofacial Biol Sci, Baltimore, MD 21201 USA

[3] Chinese Acad Sci, Shanghai Inst Life Sci, Inst Neurosci, Shanghai 200031, Peoples R China

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 21期

关键词：

D O I：

10.1073/pnas.211373398

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Persistent or chronic pain is the primary reason people seek medical care, yet current therapies are either inadequate for certain types of pain or cause intolerable side effects. Recently, pain neurobiologists have identified a number of cellular and molecular processes that lead to the initiation and maintenance of pain. Understanding these underlying mechanisms has given significant promise for the development of more effective, more specific pain therapies in the near future.

引用

页码：11845 / 11846

页数：2

共 18 条

[11] Ion channels of nociception [J].

McCleskey, EW ;

Gold, MS .

ANNUAL REVIEW OF PHYSIOLOGY, 1999, 61 :835-856

[12] IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life [J].

Molliver, DC ;

Wright, DE ;

Leitner, ML ;

Parsadanian, AS ;

Doster, K ;

Wen, D ;

Yan, Q ;

Snider, WD .

NEURON, 1997, 19 (04) :849-861

[13] Tackling pain at the source: New ideas about nociceptors [J].

Snider, WD ;

McMahon, SB .

NEURON, 1998, 20 (04) :629-632

[14]

Stucky CL, 1999, J NEUROSCI, V19, P6497

[15]

Watson CPN, 2000, CLIN J PAIN, V16, pS49

[16] Neuroscience - Neuronal plasticity: Increasing the gain in pain [J].

Woolf, CJ ;

Salter, MW .

SCIENCE, 2000, 288 (5472) :1765-1768

[17]

Zhang X, 1998, NEUROSCIENCE, V82, P223

[18]

Zhang X, 2000, NEUROSCIENCE, V95, P197

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