A New Triterpene From Uncaria macrophylla and Its Antitumor Activity

被引：11

作者：

Sun, Guangli ^{[1
,2
,3
]}

Zhang, Xiaopo ^{[1
,2
]}

Xu, Xudong ^{[1
,2
]}

Yang, Junshan ^{[1
,2
]}

Zhong, Mingliang ^{[1
,2
]}

Yuan, Jingquan ^{[1
,2
,4
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China

[2] Peking Union Med Coll, Beijing 100193, Peoples R China

[3] Hebei United Univ, Sch Pharm, Dept Pharm, Tangshan 063000, Hebei, Peoples R China

[4] Guangxi Inst Med Plant Dev, Nanning 530023, Guangxi, Peoples R China

来源：

MOLECULES | 2012年 / 17卷 / 02期

关键词：

Uncaria macrophylla; Rubiaceae; 3; beta; 6; 19 alpha-trihydroxy-12-oleanen-28-oic acid; antitumor activity; ALKALOIDS; BARK;

D O I：

10.3390/molecules17021883

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

On our ongoing investigation, a new oleanolic triterpene, 3 beta, 6 beta, 19 alpha-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, including 1D and 2D (H-1-H-1 COSY, HSQC and HMBC) NMR and HR-ESI-MS. The cytotoxicities of the compound was evaluated against two cancer cell lines of MCF-7 and HepG2 by the MTT method, and the compound exhibited weak activities with the IC50 values of 78.2 mu g/mL and 73.9 mu g/mL.

引用

页码：1883 / 1889

页数：7

共 10 条

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