The role of neoantigens in response to immune checkpoint blockade

被引：134
作者：
Riaz, Nadeem [1 ]
Morris, Luc [2 ,3 ]
Havel, Jonathan J. [2 ]
Makarov, Vladimir [2 ]
Desrichard, Alexis [2 ]
Chan, Timothy A. [1 ,2 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, Box 20,1275 York Ave, New York, NY 10065 USA
[2] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, Box 20,1275 York Ave, New York, NY 10065 USA
[3] Mem Sloan Kettering Canc Ctr, Dept Surg, Box 20,1275 York Ave, New York, NY 10065 USA
来源：
INTERNATIONAL IMMUNOLOGY | 2016年 / 28卷 / 08期
关键词：
cancer; immunotherapy; mutation; neoantigen; CYTOLYTIC T-LYMPHOCYTES; MHC CLASS-I; TUMOR-SPECIFIC ANTIGENS; EXOME ANALYSIS REVEALS; CELL LUNG-CANCER; INTRATUMOR HETEROGENEITY; CTLA-4; BLOCKADE; PD-1; ANTI-PD-L1; ANTIBODY; ANTITUMOR IMMUNITY;
D O I：
10.1093/intimm/dxw019
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immune checkpoint blockade has demonstrated substantial promise for the treatment of several advanced malignancies. These agents activate the immune system to attack tumor cells. For example, agents targeting CTLA4 and programmed cell death 1 (PD-1) have resulted in impressive response rates and, in some cases, durable remissions. Neoantigens are mutations that encode immunologically active proteins that can cause the immune system to recognize the affected cell as foreign. Recent data have made it clear that these mutations are, in large part, the functional targets of immune checkpoint blockade. This review summarizes the key discoveries leading up to this important conclusion and discusses possible applications of neoantigens in cancer therapy.
引用
收藏
页码：411 / 419
页数：9
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