The role of neoantigens in response to immune checkpoint blockade

被引：136

作者：

Riaz, Nadeem ^{[1
]}

Morris, Luc ^{[2
,3
]}

Havel, Jonathan J. ^{[2
]}

Makarov, Vladimir ^{[2
]}

Desrichard, Alexis ^{[2
]}

Chan, Timothy A. ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, Box 20,1275 York Ave, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, Box 20,1275 York Ave, New York, NY 10065 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Surg, Box 20,1275 York Ave, New York, NY 10065 USA

来源：

INTERNATIONAL IMMUNOLOGY | 2016年 / 28卷 / 08期

关键词：

cancer; immunotherapy; mutation; neoantigen; CYTOLYTIC T-LYMPHOCYTES; MHC CLASS-I; TUMOR-SPECIFIC ANTIGENS; EXOME ANALYSIS REVEALS; CELL LUNG-CANCER; INTRATUMOR HETEROGENEITY; CTLA-4; BLOCKADE; PD-1; ANTI-PD-L1; ANTIBODY; ANTITUMOR IMMUNITY;

D O I：

10.1093/intimm/dxw019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune checkpoint blockade has demonstrated substantial promise for the treatment of several advanced malignancies. These agents activate the immune system to attack tumor cells. For example, agents targeting CTLA4 and programmed cell death 1 (PD-1) have resulted in impressive response rates and, in some cases, durable remissions. Neoantigens are mutations that encode immunologically active proteins that can cause the immune system to recognize the affected cell as foreign. Recent data have made it clear that these mutations are, in large part, the functional targets of immune checkpoint blockade. This review summarizes the key discoveries leading up to this important conclusion and discusses possible applications of neoantigens in cancer therapy.

引用

页码：411 / 419

页数：9

共 101 条

[11] Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival [J].

Brown, Scott D. ;

Warren, Rene L. ;

Gibb, Ewan A. ;

Martin, Spencer D. ;

Spinelli, John J. ;

Nelson, Brad H. ;

Holt, Robert A. .

GENOME RESEARCH, 2014, 24 (05) :743-750

[12] A NEW MEMBER OF THE IMMUNOGLOBULIN SUPERFAMILY - CTLA-4 [J].

BRUNET, JF ;

DENIZOT, F ;

LUCIANI, MF ;

ROUXDOSSETO, M ;

SUZAN, M ;

MATTEI, MG ;

GOLSTEIN, P .

NATURE, 1987, 328 (6127) :267-270

[13] Properties of MHC Class I Presented Peptides That Enhance Immunogenicity [J].

Calis, Jorg J. A. ;

Maybeno, Matt ;

Greenbaum, Jason A. ;

Weiskopf, Daniela ;

De Silva, Aruna D. ;

Sette, Alessandro ;

Kesmir, Can ;

Peters, Bjoern .

PLOS COMPUTATIONAL BIOLOGY, 2013, 9 (10)

[14] Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes [J].

Cohen, Cyrille J. ;

Gartner, Jared J. ;

Horovitz-Fried, Miryam ;

Shamalov, Katerina ;

Trebska-McGowan, Kasia ;

Bliskovsky, Valery V. ;

Parkhurst, Maria R. ;

Ankri, Chen ;

Prickett, Todd. D. ;

Crystal, Jessica S. ;

Li, Yong F. ;

El-Gamil, Mona ;

Rosenberg, Steven A. ;

Robbins, Paul F. .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (10) :3981-3991

[15] Comprehensive molecular profiling of lung adenocarcinoma [J].

Collisson, Eric A. ;

Campbell, Joshua D. ;

Brooks, Angela N. ;

Berger, Alice H. ;

Lee, William ;

Chmielecki, Juliann ;

Beer, David G. ;

Cope, Leslie ;

Creighton, Chad J. ;

Danilova, Ludmila ;

Ding, Li ;

Getz, Gad ;

Hammerman, Peter S. ;

Hayes, D. Neil ;

Hernandez, Bryan ;

Herman, James G. ;

Heymach, John V. ;

Jurisica, Igor ;

Kucherlapati, Raju ;

Kwiatkowski, David ;

Ladanyi, Marc ;

Robertson, Gordon ;

Schultz, Nikolaus ;

Shen, Ronglai ;

Sinha, Rileen ;

Sougnez, Carrie ;

Tsao, Ming-Sound ;

Travis, William D. ;

Weinstein, John N. ;

Wigle, Dennis A. ;

Wilkerson, Matthew D. ;

Chu, Andy ;

Cherniack, Andrew D. ;

Hadjipanayis, Angela ;

Rosenberg, Mara ;

Weisenberger, Daniel J. ;

Laird, Peter W. ;

Radenbaugh, Amie ;

Ma, Singer ;

Stuart, Joshua M. ;

Byers, Lauren Averett ;

Baylin, Stephen B. ;

Govindan, Ramaswamy ;

Meyerson, Matthew ;

Rosenberg, Mara ;

Gabriel, Stacey B. ;

Cibulskis, Kristian ;

Sougnez, Carrie ;

Kim, Jaegil ;

Stewart, Chip .

NATURE, 2014, 511 (7511) :543-550

[16] A NEW GENE CODING FOR A DIFFERENTIATION ANTIGEN RECOGNIZED BY AUTOLOGOUS CYTOLYTIC T-LYMPHOCYTES ON HLA-A2 MELANOMAS [J].

COULIE, PG ;

BRICHARD, V ;

VANPEL, A ;

WOLFEL, T ;

SCHNEIDER, J ;

TRAVERSARI, C ;

MATTEI, S ;

DEPLAEN, E ;

LURQUIN, C ;

SZIKORA, JP ;

RENAULD, JC ;

BOON, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (01) :35-42

[17] A MUTATED INTRON SEQUENCE CODES FOR AN ANTIGENIC PEPTIDE RECOGNIZED BY CYTOLYTIC T-LYMPHOCYTES ON A HUMAN-MELANOMA [J].

COULIE, PG ;

LEHMANN, F ;

LETHE, B ;

HERMAN, J ;

LURQUIN, C ;

ANDRAWISS, M ;

BOON, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) :7976-7980

[18] Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy [J].

Coulie, Pierre G. ;

Van den Eynde, Benoit J. ;

van der Bruggen, Pierre ;

Boon, Thierry .

NATURE REVIEWS CANCER, 2014, 14 (02) :135-146

[19]

Dong HD, 2002, NAT MED, V8, P793, DOI 10.1038/nm730

[20] The immunobiology of cancer immunosurveillance and immunoediting [J].

Dunn, GP ;

Old, LJ ;

Schreiber, RD .

IMMUNITY, 2004, 21 (02) :137-148

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