Atherosclerosis in HIV Patients: What Do We Know so Far?

被引:11
作者
Poznyak, Anastasia V. [1 ]
Bezsonov, Evgeny E. [2 ,3 ,4 ]
Borisov, Evgeny E. [2 ]
Grechko, Andrey V. [5 ]
Kartuesov, Andrey G. [3 ]
Orekhov, Alexander N. [1 ,2 ,3 ]
机构
[1] Atherosclerosis Res Inst, Skolkovo Innovat Ctr, Moscow 121609, Russia
[2] AP Avtsyn Res Inst Human Morphol, 3 Tsyurupa St, Moscow 117418, Russia
[3] Inst Gen Pathol & Pathophysiol, Lab Angiopathol, 8 Baltiiskaya St, Moscow 125315, Russia
[4] Sechenov Univ, Dept Biol & Gen Genet, IM Sechenov First Moscow State Med Univ, 8 Izmailovsky Blvd, Moscow 105043, Russia
[5] Fed Res & Clin Ctr Intens Care Med & Rehabilitol, 14-3 Solyanka St, Moscow 109240, Russia
基金
俄罗斯科学基金会;
关键词
atherosclerosis; HIV; immunity; ENDOPLASMIC-RETICULUM STRESS; ANTIRETROVIRAL THERAPY; CARDIOVASCULAR-DISEASE; PLASMA TRIGLYCERIDES; NLRP3; INFLAMMASOME; INFECTED PATIENTS; STATIN USE; RISK; IMMUNODEFICIENCY; DYSLIPIDEMIA;
D O I
10.3390/ijms23052504
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
For the past several decades, humanity has been dealing with HIV. This disease is one of the biggest global health problems. Fortunately, modern antiretroviral therapy allows patients to manage the disease, improving their quality of life and their life expectancy. In addition, the use of these drugs makes it possible to reduce the risk of transmission of the virus to almost zero. Atherosclerosis is another serious pathology that leads to severe health problems, including disability and, often, the death of the patient. An effective treatment for atherosclerosis has not yet been developed. Both types of immune response, innate and adaptive, are important components of the pathogenesis of this disease. In this regard, the peculiarities of the development of atherosclerosis in HIV carriers are of particular scientific interest. In this review, we have tried to summarize the data on atherosclerosis and its development in HIV carriers. We also looked at the classic therapeutic methods and their features concerning the concomitant diagnosis.
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页数:14
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