Atherosclerosis in HIV Patients: What Do We Know so Far?

被引:11
作者
Poznyak, Anastasia V. [1 ]
Bezsonov, Evgeny E. [2 ,3 ,4 ]
Borisov, Evgeny E. [2 ]
Grechko, Andrey V. [5 ]
Kartuesov, Andrey G. [3 ]
Orekhov, Alexander N. [1 ,2 ,3 ]
机构
[1] Atherosclerosis Res Inst, Skolkovo Innovat Ctr, Moscow 121609, Russia
[2] AP Avtsyn Res Inst Human Morphol, 3 Tsyurupa St, Moscow 117418, Russia
[3] Inst Gen Pathol & Pathophysiol, Lab Angiopathol, 8 Baltiiskaya St, Moscow 125315, Russia
[4] Sechenov Univ, Dept Biol & Gen Genet, IM Sechenov First Moscow State Med Univ, 8 Izmailovsky Blvd, Moscow 105043, Russia
[5] Fed Res & Clin Ctr Intens Care Med & Rehabilitol, 14-3 Solyanka St, Moscow 109240, Russia
基金
俄罗斯科学基金会;
关键词
atherosclerosis; HIV; immunity; ENDOPLASMIC-RETICULUM STRESS; ANTIRETROVIRAL THERAPY; CARDIOVASCULAR-DISEASE; PLASMA TRIGLYCERIDES; NLRP3; INFLAMMASOME; INFECTED PATIENTS; STATIN USE; RISK; IMMUNODEFICIENCY; DYSLIPIDEMIA;
D O I
10.3390/ijms23052504
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
For the past several decades, humanity has been dealing with HIV. This disease is one of the biggest global health problems. Fortunately, modern antiretroviral therapy allows patients to manage the disease, improving their quality of life and their life expectancy. In addition, the use of these drugs makes it possible to reduce the risk of transmission of the virus to almost zero. Atherosclerosis is another serious pathology that leads to severe health problems, including disability and, often, the death of the patient. An effective treatment for atherosclerosis has not yet been developed. Both types of immune response, innate and adaptive, are important components of the pathogenesis of this disease. In this regard, the peculiarities of the development of atherosclerosis in HIV carriers are of particular scientific interest. In this review, we have tried to summarize the data on atherosclerosis and its development in HIV carriers. We also looked at the classic therapeutic methods and their features concerning the concomitant diagnosis.
引用
收藏
页数:14
相关论文
共 50 条
  • [21] NLRC5 Functions beyond MHC I Regulation - What Do We Know So Far?
    Benkoe, Szilvia
    Kovacs, Elek Gergoe
    Hezel, Felix
    Kufer, Thomas A.
    FRONTIERS IN IMMUNOLOGY, 2017, 8
  • [22] Drug-Drug Interactions Between HIV Antivirals and Concomitant Drugs in HIV Patients: What We Know and What We Need to Know
    De Bellis, Emanuela
    Donnarumma, Danilo
    Zarrella, Adele
    Mazzeo, Salvatore Maria
    Pagano, Annarita
    Manzo, Valentina
    Mazza, Ines
    Sabbatino, Francesco
    Corbi, Graziamaria
    Pagliano, Pasquale
    Filippelli, Amelia
    Conti, Valeria
    PHARMACEUTICS, 2025, 17 (01)
  • [23] Treatment as prevention trials and ending AIDS: what do we know, when did we know it, and what do we do now?
    Granich, Reuben
    Williams, Brian G.
    CURRENT OPINION IN HIV AND AIDS, 2019, 14 (06) : 514 - 520
  • [24] Contralateral Prophylactic Mastectomy: What Do We Know and What Do Our Patients Know?
    Khan, Seema A.
    JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (16) : 2132 - 2135
  • [25] SARS-CoV-2, COVID-19, skin and immunology - What do we know so far?
    Novak, Natalijia
    Peng, Wenming
    Naegeli, Mirjam C.
    Galvan, Christina
    Kolm-Djamei, Isabel
    Brueggen, Charlotte
    Cabanillas, Beatriz
    Schmid-Grendelmeier, Peter
    Catala, Alba
    ALLERGY, 2021, 76 (03) : 698 - 713
  • [26] Inflammatory Diseases and Vitamin E-What Do We Know and Where Do We Go?
    Wallert, Maria
    Boermel, Lisa
    Lorkowski, Stefan
    MOLECULAR NUTRITION & FOOD RESEARCH, 2021, 65 (01)
  • [27] Methylglyoxal and Advanced Glycation End Products in Patients with Diabetes - What We Know so Far and the Missing Links
    Groener, Jan Benedikt
    Oikonomou, Dimitrios
    Cheko, Ruan
    Render, Zoltan
    Zemva, Johanna
    Kihm, Lars
    Muckenthaler, Martina
    Peters, Verena
    Fleming, Thomas
    Kopf, Stefan
    Nawroth, Peter P.
    EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2019, 127 (08) : 497 - 504
  • [28] Adjuvants approved for human use: What do we know and what do we need to know for designing good adjuvants?
    Reyes, Cesar
    Patarroyo, Manuel A.
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2023, 945
  • [29] Treatment of Early Syphilis in HIV: What Do We Really Know?
    White, A. Clinton, Jr.
    CLINICAL INFECTIOUS DISEASES, 2017, 64 (06) : 765 - 766
  • [30] Intestinal Microbiota and Aging in People with HIV-What We Know and What We Don't
    Islam, S. M. Shamsul
    Singh, Shalini
    Keshavarzian, Ali
    Abdel-Mohsen, Mohamed
    CURRENT HIV/AIDS REPORTS, 2025, 22 (01)