Antifungal compounds of Xylaria sp., an endophytic fungus isolated from Palicourea marcgravii (Rubiaceae)

被引:41
作者
Cafeu, Mariana C.
Silva, Geraldo H.
Teles, Helder L.
Bolzani, Vanderlan Da S.
Araujo, Angela R. [1 ]
Young, Maria Claudia M.
Pfenning, Ludwig H.
机构
[1] Univ Estadual Paulista, Inst Quim, BR-14801 Araraquara, SP, Brazil
[2] Inst Bot, Secao Fisiol & Bioquim Plantas, BR-01061 Sao Paulo, SP, Brazil
[3] Univ Fed Lavras, Dept Fitopatol, BR-37200 Lavras, MG, Brazil
来源
QUIMICA NOVA | 2005年 / 28卷 / 06期
关键词
endophytic fungus; Xylaria sp; antifungal compounds;
D O I
10.1590/S0100-40422005000600011
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Five compounds, 2-hexyl-3-methyl-butanodioic acid (1), cytochalasin D (2), 7-dechlorogriseofulvin (3), cytochalasin B (4) and griseofulvin (5), have been isolated from the endophytic fungus Xylaria sp., and their structures were elucidated on the basis of spectroscopic data. In the bioautography assay against Cladosporium cladosporioides and Cladosporium sphaerospermum, compounds 1 and 2 were found to be active while compounds 3, 4 and 5 did not show antifungal activity.
引用
收藏
页码:991 / 995
页数:5
相关论文
共 12 条
[1]  
AZEVEDO JL, 1998, ECOLOGIA MICROBIANA, P116
[2]   Biosynthesis of the fungal metabolite, piliformic acid (2-hexylidene-3-methylsuccinic acid) [J].
Chesters, NCJE ;
OHagan, D .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1997, (06) :827-834
[3]   Small bugs, big business: The economic power of the microbe [J].
Demain, AL .
BIOTECHNOLOGY ADVANCES, 2000, 18 (06) :499-514
[4]  
Dreyfuss M M, 1994, Biotechnology, V26, P49
[5]   Zygosporin D and two new cytochalasins produced by the fungus Metarrhizium anisopliae [J].
Fujii, Y ;
Tani, H ;
Ichinoe, M ;
Nakajima, H .
JOURNAL OF NATURAL PRODUCTS, 2000, 63 (01) :132-135
[6]   BIOSYNTHESIS OF CYTOCHALASANS .3. C-13-NMR OF CYTOCHALASIN-B (PHOMIN) AND CYTOCHALASIN-D - INCORPORATION OF [1-C-13]- AND [2-C-13]-SODIUM ACETATE [J].
GRAF, W ;
ROBERT, JL ;
VEDERAS, JC ;
TAMM, C ;
SOLOMON, PH ;
MIURA, I ;
NAKANISHI, K .
HELVETICA CHIMICA ACTA, 1974, 57 (06) :1801-1815
[7]   DIRECT BIOAUTOGRAPHY ON THIN-LAYER CHROMATOGRAMS AS A METHOD FOR DETECTING FUNGITOXIC SUBSTANCES [J].
HOMANS, AL ;
FUCHS, A .
JOURNAL OF CHROMATOGRAPHY, 1970, 51 (02) :327-&
[8]   Geniculol, a new biologically active diterpene from the endophytic fungus Geniculosporium sp. [J].
König, GM ;
Wright, AD ;
Aust, HJ ;
Draeger, S ;
Schulz, B .
JOURNAL OF NATURAL PRODUCTS, 1999, 62 (01) :155-157
[9]   THE CONFORMATION OF CYTOCHALASIN-D IN DMSO SOLUTION FROM H-1 AND C-13 NMR RELAXATION RATES [J].
MACCOTTA, A ;
VALENSIN, G ;
GAGGELLI, N ;
GAGGELLI, E .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1993, (04) :729-732
[10]   Accumulation of sesquiterpenoid cyclohexenone derivatives induced by an arbuscular mycorrhizal fungus in members of the Poaceae [J].
Maier, W ;
Hammer, K ;
Dammann, U ;
Schulz, B ;
Strack, D .
PLANTA, 1997, 202 (01) :36-42