Silver(I)-catalyzed facile synthesis of pyrazoles from propargyl N-sulfonylhydrazones

被引：68
作者：
Lee, Young Tak [1 ]
Chung, Young Keun [1 ]
机构：
[1] Seoul Natl Univ, Intelligent Text Syst Res Ctr, Dept Chem, Coll Nat Sci, Seoul 151747, South Korea
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 12期
关键词：
D O I：
10.1021/jo800663g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A silver(I)-catalyzed facile formation of pyrazoles from propargyl N-sulfonylhydrazones has been disclosed. During the reaction, a migration of sulfonyl groups (Ts, Ms) was observed. Good functional group compatibility was observed under mild reaction conditions (at room temperature for 3-5 h). This methodology allows for the efficient and regioselective synthesis of 1,3- and 1,5-disubstituted and 1,3,5-trisubstituted pyrazoles.
引用
收藏
页码：4698 / 4701
页数：4
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