Segmental Mandibular Reconstruction with Freeze-Dried Bone and Bone Marrow Mesenchymal Stem Cells in Beagles

被引：0
|
作者：
Wang, Hong [1 ]
Wu, Tao [2 ]
Zhao, Bingjing [1 ]
Luo, Jinchao [1 ]
Hu, Min [1 ]
Liu, Changkui [3 ]
机构：
[1] Peoples Liberat Army, Gen Hosp, Dept Stomatol, 28 Fuxing Rd, Beijing, Peoples R China
[2] Gaoxin Hosp, Dept Neurol, Xian, Peoples R China
[3] Peoples Liberat Army, Hosp 451, Dept Stomatol, 269 Friendship Rd, Xian, Peoples R China
来源：
ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY | 2016年 / 38卷 / 04期
基金：
北京市自然科学基金;
关键词：
allogeneic transplantation; allografts; bone; bone formation; bone marrow stromal cell; bone tissue; bone tissue engineering; mandibular osteotomy; mandibular reconstruction; mesenchymal stem cells; mesenchymal stromal cells; multi potent bone marrow stromal cells; multipotent mesenchymal stromal cells; osteogenesis; regeneration; stem cells; STROMAL CELLS; DEFECTS; TRANSPLANTATION; ALLOGRAFTS; REPAIR; CORD;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
OBJECTIVE: Bone marrow derived mesenchymal stem cells (BM-MSCs) are multipotential cells. However, the harvest of autologous MSCs can be difficult due to the age or poor physical status of patients. The aim of this study was to investigate the reconstructive effect of allogeneic BM-MSCs on segmental mandibular defects. STUDY DESIGN: Freeze-dried and perforated mandibles of beagles were prepared as scaffolds. The right mandibular body of 24 female beagles was cut into 30 mm to create a segmental defect. The defects were randomly repaired with allogeneic freeze-dried bone (group A) or allogeneic MSCs and freeze-dried bone (group B). The reconstructive effects on the 2 groups were assessed by conducting computerized tomography scanning and histological analyses. RESULTS: The continuity and integrity of both groups were restored. The osseous maturation of group B was higher than that of group A. CONCLUSION: Allogeneic MSCs can promote new bone formation and improve the reconstructive effect on segmental defects.
引用
收藏
页码：221 / 228
页数：8
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