Risk Factors for Heart Failure in the Community: Differences by Age and Ejection Fraction

被引：34

作者：

Chamberlain, Alanna M. ^{[1
]}

Boyd, Cynthia M. ^{[2
]}

Manemann, Sheila M. ^{[1
]}

Dunlay, Shannon M. ^{[3
]}

Gerber, Yariv ^{[4
]}

Killian, Jill M. ^{[1
]}

Weston, Susan A. ^{[1
]}

Roger, Veronique L. ^{[1
,3
]}

机构：

[1] Mayo Clin, Dept Hlth Sci Res, 200 First St SW, Rochester, MN 55905 USA

[2] Johns Hopkins Univ, Div Geriatr Med & Gerontol, Baltimore, MD USA

[3] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN USA

[4] Tel Aviv Univ, Sch Publ Hlth, Dept Epidemiol & Prevent Med, Tel Aviv, Israel

来源：

AMERICAN JOURNAL OF MEDICINE | 2020年 / 133卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Case-control study; Heart failure; Risk factors; MEDICAL-RECORDS-LINKAGE; LIFETIME RISK; EPIDEMIOLOGY; HOSPITALIZATIONS; POPULATION; SURVIVAL; TRENDS;

D O I：

10.1016/j.amjmed.2019.10.030

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: Differences in comorbid conditions in patients with heart failure compared with population controls, and whether differences exist by type of heart failure or age, have not been well documented. METHODS: The prevalence of 17 chronic conditions were obtained in 2643 patients with incident heart failure from 2000 to 2013 and controls matched 1:1 on sex and age from Olmsted County, Minnesota. Logistic regression determined associations of each condition with heart failure. RESULTS: Among 2643 matched pairs (mean age 76.2 years, 45.6% men), the comorbidities with the largest attributable risk of heart failure were arrhythmia (48.7%), hypertension (28.4%), and coronary artery disease (33.9%); together these explained 73.0% of heart failure. Similar associations were observed for patients with reduced and preserved ejection fraction, with the exception of hypertension. The risk of heart failure attributable to hypertension was 2-fold higher in patients with heart failure with preserved ejection fraction (38.7%) than in patients with heart failure with reduced ejection fraction (17.8%). Hypertension, coronary artery disease, arrhythmia, and diabetes were more strongly associated with heart failure in younger (<= 75 years) compared to older (>75 years) persons. CONCLUSIONS: Patients with heart failure have a higher prevalence of many chronic conditions than controls. Similar associations were observed in patients with reduced and preserved ejection fraction, with the exception of hypertension, which was more strongly associated with heart failure with preserved ejection fraction. Finally, some cardiometabolic risk factors were more strongly associated with heart failure in younger persons, highlighting the importance of optimizing prevention and treatment of risk factors and, in particular, cardiometabolic risk factors. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：E237 / E248

页数：12

共 33 条

[1]

Benjamin EJ, 2019, CIRCULATION, V139, pE56, DOI [10.1161/CIR.0000000000000746, 10.1161/CIR.0000000000000659]

[2] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[3] Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure - The Rotterdam Study [J].

Bleumink, GS ;

Knetsch, AM ;

Sturkenboom, MCJM ;

Straus, SMJM ;

Hofman, A ;

Deckers, JW ;

Witteman, JCM ;

Stricker, BHC .

EUROPEAN HEART JOURNAL, 2004, 25 (18) :1614-1619

[4] Burden and Timing of Hospitalizations in Heart Failure: A Community Study [J].

Chamberlain, Alanna M. ;

Dunlay, Shannon M. ;

Gerber, Yariv ;

Manemann, Sheila M. ;

Jiang, Ruoxiang ;

Weston, Susan A. ;

Roger, Veronique L. .

MAYO CLINIC PROCEEDINGS, 2017, 92 (02) :184-192

[5] Multimorbidity in Heart Failure: A Community Perspective [J].

Chamberlain, Alanna M. ;

St Sauver, Jennifer L. ;

Gerber, Yariv ;

Manemann, Sheila M. ;

Boyd, Cynthia M. ;

Dunlay, Shannon M. ;

Rocca, Walter A. ;

Rutten, Lila J. Finney ;

Jiang, Ruoxiang ;

Weston, Susan A. ;

Roger, Veronique L. .

AMERICAN JOURNAL OF MEDICINE, 2015, 128 (01) :38-45

[6] Risk factors for heart failure in the elderly: A prospective community-based study [J].

Chen, YT ;

Vaccarino, V ;

Williams, CS ;

Butler, J ;

Berkman, LF ;

Krumholz, HM .

AMERICAN JOURNAL OF MEDICINE, 1999, 106 (06) :605-612

[7] Hospitalizations After Heart Failure Diagnosis A Community Perspective [J].

Dunlay, Shannon M. ;

Redfield, Margaret M. ;

Weston, Susan A. ;

Therneau, Terry M. ;

Long, Kirsten Hall ;

Shah, Nilay D. ;

Roger, Veronique L. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 54 (18) :1695-1702

[8] Risk Factors for Heart Failure: A Population-Based Case-Control Study [J].

Dunlay, Shannon M. ;

Weston, Susan A. ;

Jacobsen, Steven J. ;

Roger, Veronique L. .

AMERICAN JOURNAL OF MEDICINE, 2009, 122 (11) :1023-1028

[9] A Contemporary Appraisal of the Heart Failure Epidemic in Olmsted County, Minnesota, 2000 to 2010 [J].

Gerber, Yariv ;

Weston, Susan A. ;

Redfield, Margaret M. ;

Chamberlain, Alanna M. ;

Manemann, Sheila M. ;

Jiang, Ruoxiang ;

Killian, Jill M. ;

Roger, Veronique L. .

JAMA INTERNAL MEDICINE, 2015, 175 (06) :996-1004

[10] Risk factors for incident heart failure with preserved or reduced ejection fraction, and valvular heart failure, in a community-based cohort [J].

Gong, Fei Fei ;

Jelinek, Michael, V ;

Castro, Julian M. ;

Coller, Jennifer M. ;

McGrady, Michele ;

Boffa, Umberto ;

Shiel, Louise ;

Liew, Danny ;

Wolfe, Rory ;

Stewart, Simon ;

Owen, Alice J. ;

Krum, Henry ;

Reid, Christopher M. ;

Prior, David L. ;

Campbell, Duncan J. .

OPEN HEART, 2018, 5 (02)

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