Immunoregulation and antioxidant activities of a novel acidic polysaccharide from Radix Paeoniae Alba

被引：28
|
作者：
Zhang, Wuxia [1 ]
Hu, Yihua [1 ]
Zhao, Jinzhong [1 ]
Zhang, Yongpo [1 ]
Guo, Dongdong [1 ]
Gao, Chunyan [1 ]
Duan, Jinyou [2 ]
Li, Peng [1 ]
机构：
[1] Shanxi Agr Univ, Coll Arts & Sci, Taigu 030801, Shanxi, Peoples R China
[2] Northwest Agr & Forestry Univ, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China
来源：
GLYCOCONJUGATE JOURNAL | 2020年 / 37卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Radix Paeoniae Alba; Ranunculus; Acidic polysaccharide; Immune activity; Antioxidant activity; STRUCTURAL-CHARACTERIZATION; PECTIC POLYSACCHARIDE; IMMUNOMODULATORY ACTIVITIES; SULFATED POLYSACCHARIDE; LACTIFLORA-PALL; PC12; CELLS; BIOACTIVITIES; PURIFICATION; EXTRACTION; APOPTOSIS;
D O I：
10.1007/s10719-020-09916-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Radix Paeoniae Alba is widely used in Chinese traditional medicine to treat various diseases such as gastrointestinal disorders, immunomodulatory, cancer, and other diseases. In this paper, a novel acidic polysaccharide RPAPS purified from Radix Paeoniae Alba was evaluated for its structural features and potential of immunomodulatory and antioxidant activities. RPAPS (molecular weight: 1.0x 10(5) Da) was mainly composed of alpha-(1 -> 4)-Glcp, alpha-Arap, alpha-Galp, alpha-Rhap, beta-D-Glcp, alpha-(1 -> 6)-linked Glcp and GalA. Immunological tests indicated that RPAPS could improve RAW264.7 phagocytic activity and LPS-induced splenocyte proliferation. For antioxidant activities, RPAPS showed reducing power and DPPH scavenging activity in dose dependent. Moreover, RPAPS could significantly protect the PC12 cells from H2O2 damage. These data implied polysaccharides RPAPS had the potential to be novel natural antioxidative and immunopotentiating agents for using in functional foods or medicine.
引用
收藏
页码：361 / 371
页数：11
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