Epigenetic Reprogramming During Somatic Cell Nuclear Transfer: Recent Progress and Future Directions

被引：40

作者：

Wang, Xiangyu ^{[1
]}

Qu, Jiadan ^{[1
]}

Li, Jie ^{[2
]}

He, Hongbin ^{[3
]}

Liu, Zhonghua ^{[4
]}

Huan, Yanjun ^{[1
]}

机构：

[1] Qingdao Agr Univ, Coll Vet Med, Qingdao, Peoples R China

[2] Qingdao Municipal Hosp, Dept Cadre Hlth Care, Qingdao, Peoples R China

[3] Shandong Normal Univ, Coll Life Sci, Jinan, Peoples R China

[4] Northeast Agr Univ, Coll Life Sci, Harbin, Peoples R China

来源：

FRONTIERS IN GENETICS | 2020年 / 11卷

基金：

中国国家自然科学基金;

关键词：

somatic cell nuclear transfer; cloning efficiency; nuclear reprogramming; epigenetic modification; long non-coding RNA; LONG NONCODING RNAS; X-CHROMOSOME INACTIVATION; FULL-TERM DEVELOPMENT; EMBRYONIC STEM-CELLS; DNA METHYLATION; GENE-EXPRESSION; DONOR CELLS; GENOME-WIDE; ABERRANT EXPRESSION; MEDIATED KNOCKDOWN;

D O I：

10.3389/fgene.2020.00205

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Somatic cell nuclear transfer (SCNT) has broad applications but is limited by low cloning efficiency. In this review, we mainly focus on SCNT-mediated epigenetic reprogramming in livestock and also describe mice data for reference. This review presents the factors contributing to low cloning efficiency, demonstrates that incomplete epigenetic reprogramming leads to the low developmental potential of cloned embryos, and further describes the regulation of epigenetic reprogramming by long non-coding RNAs, which is a new research perspective in the field of SCNT-mediated epigenetic reprogramming. In conclusion, this review provides new insights into the epigenetic regulatory mechanism during SCNT-mediated nuclear reprogramming, which could have great implications for improving cloning efficiency.

引用

页数：13

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