Antibodies to hepatitis B virus surface antigen and survival of hemodialysis patients - a prospective study

被引：11

作者：

Grzegorzewska, Alicja E. ^{[1
]}

Swiderska, Monika K. ^{[2
]}

Warchol, Wojciech ^{[3
]}

机构：

[1] PUMS, Dept Nephrol Transplantol & Internal Dis, 49 Przybyszewskiego Blvd, PL-60355 Poznan, Poland

[2] PUMS, Student Nephrol Res Grp, Poznan, Poland

[3] PUMS, Dept Biophys, Poznan, Poland

来源：

EXPERT REVIEW OF VACCINES | 2016年 / 15卷 / 08期

关键词：

Age; anti-HBs titer; coronary artery disease; diabetic nephropathy; HBV infection; HBV vaccination; hemodialysis; hepatitis B virus; parathyroid hormone; survival probability; CYTOKINE GENE POLYMORPHISMS; CHRONIC INFLAMMATION; ACQUIRED-IMMUNITY; ARTERY-DISEASE; CONTINENTS; VACCINATION; MORTALITY; DIALYSIS; IMMUNIZATION; NONRESPONSE;

D O I：

10.1080/14760584.2016.1188697

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Antibodies to hepatitis B virus (HBV) surface antigen (anti-HBs) may develop in response to HBV vaccination or infection. We investigated whether anti-HBs are an independent predictor of survival in hemodialysis (HD) patients. Methods: A 6-year prospective study was conducted in 532 HD patients. Survival analyses were performed using the Kaplan-Meier method and the Cox proportional hazard model. Results: In HBV non-infected patients, age (P = 0.005), coronary artery disease (P = 0.002), and non-response to HBV vaccine (P = 0.008) were the independent risk factors of all-cause mortality. In HBV infected patients, the only independent predictor of all-cause mortality was coronary artery disease (P = 0.002). Conclusion: The ability to produce the protective anti-HBs titer in response to HBV vaccine is a positive predictor of survival in HBV non-infected HD patients.

引用

页码：1063 / 1074

页数：12

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