Application of Supramolecular Chemistry on Pharmaceutical Cocrystals

被引：0
作者：
Chen Jia-Mei [1 ]
Wu Chuan-Bin [1 ]
Lu Tong-Bu [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 511400, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 511400, Guangdong, Peoples R China
来源：
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2011年 / 32卷 / 09期
关键词：
Supramolecular chemistry; Pharmaceutical cocrystal; Hydrogen bond; Supramolecular synthon; CO-CRYSTALS; CARBOXYLIC-ACIDS; MOLECULAR-COMPLEXES; SOLUBILITY; SALTS; INGREDIENTS; CAFFEINE; IMPROVE; DRUG; MECHANOCHEMISTRY;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Pharmaceutical cocrystal is a new type of pharmaceutical crystalline state. It is attractive to pharmaceutical scientists because it can provide a number of crystalline states for a given active pharmaceutical ingredient(API), in which the physical and chemical properties of the API can be adjusted by pharmaceutical cocrystal. In this review, we address pharmaceutical coerystals from the perspective of supramolecular chemistry, and present a series of structures of pharmaceutical cocrystals constructed through hydrogen bonding supramolecular synthons, in which the physical and chemical properties(solubility, dissolution, bioavailability, melting point, stability, etc.) of APIs can be changed by pharmaceutical cocrystal.
引用
收藏
页码：1996 / 2009
页数：14
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