Serum 25-Hydroxyvitamin D Levels in Patients with Vulvar Cancer

被引:0
作者
Salehin, Darius [1 ]
Haugk, Christina [1 ]
Thill, Marc [3 ]
Cordes, Tim [3 ]
Hornung, Daniela [3 ]
Abu-Hechle, Andre [2 ]
Hemmerlein, Bernhard
Friedrich, Michael [1 ]
机构
[1] Helios Hosp Krefeld, Dept Gynecol & Obstet, D-47805 Krefeld, Germany
[2] Helios Hosp Krefeld, Inst Lab Med, D-47805 Krefeld, Germany
[3] Med Univ Lubeck, Dept Obstet & Gynecol, D-23538 Lubeck, Germany
关键词
25-Hydroxyvitamin D; Vitamin D; Vulvar Cancer; VITAMIN-D-RECEPTOR; BREAST-CANCER; RISK; HEALTH; 1,25-DIHYDROXYVITAMIN-D; D-1-ALPHA-HYDROXYLASE; D-24-HYDROXYLASE; MORTALITY; BENIGN; CELLS;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The anticarcinogenic potential of vitamin D 25(OH)D has been attributed to the inhibition of proliferation of cells from different carcinomas. Reduced serum levels of 25(OH)D are associated with an increased incidence of various types of cancer. The influence of serum 25(OH)D on the incidence and outcome of patients with vulvar cancer is unknown. Patients and Methods: The serum 25(OH)D levels in 24 patients with vulvar cancer and 24 age-matched cancer-free patients was investigated. The blood samples were collected between October 2009 and September 2010 and time of blood collection of each patient and control was matched to avoid seasonal variations between the pairs. Results: The median 25(OH)D serum levels in the under 50 year old group of patients were significantly lower in the vulvar cancer group than the controls. The younger cancer group also had an age-related trend of lower median serum level than the older population. In the control population the trend was viceversa, yet this finding was not statistically significant. Conclusion: Serum 25(OH)D has a possible role in the pathogenesis and progression of vulvar cancer, but further investigations of the association of vitamin D and vulvar cancer as well as regarding its influence on patient survival and quality of life are warranted in the future.
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收藏
页码:265 / 270
页数:6
相关论文
共 50 条
[1]   BENEFICIAL-EFFECTS OF SUN EXPOSURE ON CANCER MORTALITY [J].
AINSLEIGH, HG .
PREVENTIVE MEDICINE, 1993, 22 (01) :132-140
[2]  
[Anonymous], 2004, KREBS DEUTSCHL HAUF
[3]  
Barreto AM, 2000, CANCER EPIDEM BIOMAR, V9, P265
[4]   Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancer [J].
Bertone-Johnson, ER ;
Chen, WY ;
Holick, MF ;
Hollis, BW ;
Colditz, GA ;
Willett, WC ;
Hankinson, SE .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (08) :1991-1997
[5]  
Cannell JJ, 2008, ALTERN MED REV, V13, P6
[6]  
Cordes T, 2010, EUR J GYNAECOL ONCOL, V31, P151
[7]   Vitamin D [J].
Dusso, AS ;
Brown, AJ ;
Slatopolsky, E .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2005, 289 (01) :F8-F28
[8]   Vitamin D signaling is modulated on multiple levels in health and disease [J].
Ebert, R ;
Schütze, N ;
Adamski, J ;
Jakob, F .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2006, 248 (1-2) :149-159
[9]  
EISMAN JA, 1980, LANCET, V1, P1188
[10]  
Fischer D, 2009, ANTICANCER RES, V29, P3641