Age-related elemental change in bones

被引：15
|
作者：
Wang, C.
Eisa, M. H.
Jin, W. [1 ,2 ]
Shen, H.
Mi, Y.
Gao, J. [1 ,2 ]
Zhou, Y. [1 ,2 ]
Yao, H.
Zhao, Y. [3 ]
机构：
[1] Fudan Univ, Inst Modern Phys, Shanghai 200433, PR, Peoples R China
[2] Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
[3] Inst High Energy Phys, Beijing 100049, Peoples R China
来源：
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS | 2008年 / 266卷 / 08期
基金：
中国国家自然科学基金;
关键词：
age; strontium; calcium; PIXE; XAFS; osteoporosis;
D O I：
10.1016/j.nimb.2008.01.015
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
To investigate age dependence of the bone element contents and structure, lumbar and femur from Sprague-Dawley (SD) rats were chosen for their more susceptibility to fracture. These rats were divided into to 5 age groups: 1, 4, 7, 11 and 25 month-age, corresponding human beings from the young to the old. The elements contents were detected by external Proton Induced X-ray emission (PIXE) technique. X-ray Absorption Fine Structure (XAFS) method was also applied to obtain information about calcium (Ca) and phosphor (P) structure. It was found that Ca content, Ca/P ratio, valance state of Ca and P and their coordinate structure remains unaltered with age variance, whereas the content of strontium (Sr) was significantly decreasing. Sr concentration may provide a new parameter for diagnosis of bone disorder. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：1619 / 1622
页数：4
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