Chronic Musculoskeletal Pain Moderates the Association between Sleep Quality and Dorsostriatal-Sensorimotor Resting State Functional Connectivity in Community-Dwelling Older Adults

被引:3
作者
Montesino-Goicolea, Soamy [1 ,2 ,3 ]
Valdes-Hernandez, Pedro A. [1 ,2 ,3 ]
Cruz-Almeida, Yenisel [1 ,2 ,3 ,4 ,5 ,6 ]
机构
[1] Univ Florida, Dept Community Dent & Behav Sci, Gainesville, FL 32610 USA
[2] Univ Florida, Pain Res & Intervent Ctr Excellence, Gainesville, FL 32610 USA
[3] Univ Florida, Evelyn F & William L McKnight Brain Inst, Gainesville, FL 32610 USA
[4] Univ Florida, Inst Aging, Gainesville, FL 32610 USA
[5] Univ Florida, Ctr Cognit Aging & Memory, Gainesville, FL 32610 USA
[6] Univ Florida, Dept Neurosci, Coll Med, Gainesville, FL 32610 USA
基金
美国国家科学基金会;
关键词
DIFFEOMORPHIC IMAGE REGISTRATION; PRIMARY INSOMNIA; CAUDATE-NUCLEUS; HUMAN STRIATUM; BASAL GANGLIA; DEFAULT MODE; MOTOR AREAS; PREVALENCE; NETWORKS; AGE;
D O I
10.1155/2022/4347759
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Aging is associated with poor sleep quality and greater chronic pain prevalence, with age-related changes in brain function as potential underlying mechanisms. Objective. The following cross-sectional study aimed to determine whether self-reported chronic musculoskeletal pain in community-dwelling older adults moderates the association between sleep quality and resting state functional brain connectivity (rsFC). Methods. Community-dwelling older individuals (mean age = 73.29 years) part of the NEPAL study who completed the Pittsburg Sleep Quality Index (PSQI) and a rsFC scan were included (n = 48) in the present investigation. To that end, we tested the effect of chronic pain-by-PSQI interaction on rsFC among atlas-based brain regions-of-interest, controlling for age and sex. Results and Discussion. A significant network connecting the bilateral putamen and left caudate with bilateral precentral gyrus, postcentral gyrus, and juxtapositional lobule cortex, survived global multiple comparisons (FDR; q < 0.05) and threshold-free network-based-statistics. Greater PSQI scores were significantly associated with greater dorsostriatal-sensorimotor rsFC in the no-pain group, suggesting that a state of somatomotor hyperarousal may be associated with poorer sleep quality in this group. However, in the pain group, greater PSQI scores were associated with less dorsostriatal-sensorimotor rsFC, possibly due to a shift of striatal functions toward regulation sensorimotor aspects of the pain experience, and/or aberrant cortico-striatal loops in the presence of chronic pain. This preliminary investigation advances knowledge about the neurobiology underlying the associations between chronic pain and sleep in community-dwelling older adults that may contribute to the development of effective therapies to decrease disability in geriatric populations.
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页数:12
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