Antibody response to influenza immunization in kidney transplant recipients receiving either azathioprine or mycophenolate: A controlled trial

被引:62
作者
Keshtkar-Jahromi, Maryam [1 ]
Argani, Hassan [2 ,3 ]
Rahnavardi, Mohammad [1 ]
Mirchi, Elham [3 ]
Atabak, Shahnaz [3 ]
Tara, Seied Ahmad [3 ]
Gachkar, Latif [1 ]
Noori-Froothghe, Azam [3 ]
Mokhtari-Azad, Talat [4 ]
机构
[1] Shahid Beheshti Univ Med Ctr, Infect Dis & Trop Med Res Ctr, Tehran, Iran
[2] Tabriz Univ Med Sci, Clin Lab Ctr, Drug Appl Res Ctr, Tabriz, Iran
[3] Shahid Beheshti Univ Med Ctr, Shahid Modarres Med Ctr, Clin Res & Dev Ctr, Dept Nephrol, Tehran, Iran
[4] Univ Tehran Med Sci, Dept Virol, Sch Publ Hlth, Tehran, Iran
关键词
influenza; vaccination; immunization; kidney transplant recipient; antibody response; azathioprine; mycophenolate mofetil;
D O I
10.1159/000119742
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Aims: We aimed to assess humoral immune response to the influenza vaccine in adult kidney transplant recipients (KTRs) subjected to two immunosuppressive regimens containing either mycophenolate mofetil (MMF) or azathioprine (Aza). Methods: 40 eligible KTRs (24 treated with Aza [KTRs-Aza] and 16 treated with MMF [KTRs-MMF]) and 40 matched healthy controls (HCs) were administered the trivalent 2006-2007 anti-influenza vaccine. Antibody (Ab) titers were measured before (pre-vacc) and 1 month after (post-vacc) vaccination. The proportion of protective Ab titers (i.e. >= 1:40), the serological response (i.e. >= 4-fold rise in titers) rates, and the magnitudes of change in titers were evaluated. Results: KTRs and HCs were similar in serologic responses, magnitudes of change in Ab titers, and proportions of acquired protective titers against all antigens. Whereas KTRs-MMF and KTRs-Aza were identical in magnitude of rise in titers as well as in serologic responses, KTRs-MMF did poorer in developing post-vacc-protective titers against A/H1N1 (p < 0.05). The function of the transplanted kidney has not deteriorated after vaccination. Conclusions: Anti-influenza vaccination was safe in KTRs and evoked Ab responses comparable to those of HCs. KTRs-MMF and KTRs-Aza responded almost equally to the vaccine. Annual anti-influenza vaccination can be recommended to all stable KTRs. Copyright (C) 2008 S. Karger AG, Basel.
引用
收藏
页码:654 / 660
页数:7
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