Paradoxical reversal learning enhancement by stress or prefrontal cortical damage: rescue with BDNF

被引：138

作者：

Graybeal, Carolyn ^{[1
]}

Feyder, Michael ^{[1
]}

Schulman, Emily ^{[1
]}

Saksida, Lisa M. ^{[2
,3
]}

Bussey, Timothy J. ^{[2
,3
]}

Brigman, Jonathan L. ^{[1
]}

Holmes, Andrew ^{[1
]}

机构：

[1] NIAAA, Lab Behav & Genom Neurosci, US Natl Inst Hlth, Bethesda, MD USA

[2] Univ Cambridge, Dept Expt Psychol, Med Res Council, Cambridge CB2 3EB, England

[3] Univ Cambridge, Wellcome Trust Behav & Clin Neurosci Inst, Cambridge, England

来源：

NATURE NEUROSCIENCE | 2011年 / 14卷 / 12期

关键词：

FEAR EXTINCTION; MICE; REORGANIZATION; EXPOSURE; CORTEX;

D O I：

10.1038/nn.2954

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stress affects various forms of cognition. We found that moderate stress enhanced late reversal learning in a mouse touchscreen-based choice task. Ventromedial prefrontal cortex (vmPFC) lesions mimicked the effect of stress, whereas orbitofrontal and dorsolateral striatal lesions impaired reversal. Stress facilitation of reversal was prevented by BDNF infusion into the vmPFC. These findings suggest a mechanism by which stress-induced vmPFC dysfunction disinhibits learning by alternate (for example, striatal) systems.

引用

页码：1507 / 1509

页数：3

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