Paradoxical reversal learning enhancement by stress or prefrontal cortical damage: rescue with BDNF

被引：136

作者：

Graybeal, Carolyn ^{[1
]}

Feyder, Michael ^{[1
]}

Schulman, Emily ^{[1
]}

Saksida, Lisa M. ^{[2
,3
]}

Bussey, Timothy J. ^{[2
,3
]}

Brigman, Jonathan L. ^{[1
]}

Holmes, Andrew ^{[1
]}

机构：

[1] NIAAA, Lab Behav & Genom Neurosci, US Natl Inst Hlth, Bethesda, MD USA

[2] Univ Cambridge, Dept Expt Psychol, Med Res Council, Cambridge CB2 3EB, England

[3] Univ Cambridge, Wellcome Trust Behav & Clin Neurosci Inst, Cambridge, England

来源：

NATURE NEUROSCIENCE | 2011年 / 14卷 / 12期

关键词：

FEAR EXTINCTION; MICE; REORGANIZATION; EXPOSURE; CORTEX;

D O I：

10.1038/nn.2954

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stress affects various forms of cognition. We found that moderate stress enhanced late reversal learning in a mouse touchscreen-based choice task. Ventromedial prefrontal cortex (vmPFC) lesions mimicked the effect of stress, whereas orbitofrontal and dorsolateral striatal lesions impaired reversal. Stress facilitation of reversal was prevented by BDNF infusion into the vmPFC. These findings suggest a mechanism by which stress-induced vmPFC dysfunction disinhibits learning by alternate (for example, striatal) systems.

引用

页码：1507 / 1509

页数：3

共 15 条

[1] Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, Amy F. T.
[J]. NATURE REVIEWS NEUROSCIENCE, 2009, 10 (06) : 410 - 422
[2] BALLEINE B, 1992, Q J EXP PSYCHOL-B, V45, P285
[3] Pharmacological or Genetic Inactivation of the Serotonin Transporter Improves Reversal Learning in Mice
Brigman, Jonathan L.
Mathur, Poonam
Harvey-White, Judith
Izquierdo, Alicia
Saksida, Lisa M.
Bussey, Timothy J.
Fox, Stephanie
Deneris, Evan
Murphy, Dennis L.
Holmes, Andrew
[J]. CEREBRAL CORTEX, 2010, 20 (08) : 1955 - 1963
[4] Functions of frontostriatal systems in cognition: Comparative neuropsychopharmacological studies in rats, monkeys and humans
Chudasama, Y.
Robbins, T. W.
[J]. BIOLOGICAL PSYCHOLOGY, 2006, 73 (01) : 19 - 38
[5] Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making
Dias-Ferreira, Eduardo
Sousa, Joao C.
Melo, Irene
Morgado, Pedro
Mesquita, Ana R.
Cerqueira, Joao J.
Costa, Rui M.
Sousa, Nuno
[J]. SCIENCE, 2009, 325 (5940) : 621 - 625
[6] Duman Ronald S, 2009, Dialogues Clin Neurosci, V11, P239
[7] A History of Corticosterone Exposure Regulates Fear Extinction and Cortical NR2B, GluR2/3, and BDNF
Gourley, Shannon L.
Kedves, Alexia T.
Olausson, Peter
Taylor, Jane R.
[J]. NEUROPSYCHOPHARMACOLOGY, 2009, 34 (03) : 707 - 716
[8] Stress-induced prefrontal reorganization and executive dysfunction in rodents
Holmes, Andrew
Wellman, Cara L.
[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2009, 33 (06) : 773 - 783
[9] Brief uncontrollable stress causes dendritic retraction in infralimbic cortex and resistance to fear extinction in mice
Izquierdo, Alicia
Wellman, Cara L.
Holmes, Andrew
[J]. JOURNAL OF NEUROSCIENCE, 2006, 26 (21) : 5733 - 5738
[10] LIMBIC LESIONS AND PROBLEM OF STIMULUS-REINFORCEMENT ASSOCIATIONS
JONES, B
MISHKIN, M
[J]. EXPERIMENTAL NEUROLOGY, 1972, 36 (02) : 362 - +

← 1 2 →