Determinations of morin, quercetin and their conjugate metabolites in serum

被引：30

作者：

Hsiu, SL

Tsao, CW

Tsai, YC

Ho, HJ

Chao, PDL ^{[1
]}

机构：

[1] China Med Coll, Sch Pharm, Taichung 404, Taiwan

[2] China Med Coll, Grad Inst Pharmaceut Chem, Taichung 404, Taiwan

[3] China Med Coll, Grad Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2001年 / 24卷 / 08期

关键词：

morin; quercetin; serum; HPLC;

D O I：

10.1248/bpb.24.967

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Morin and quercetin are isomeric antioxidant flavonols. High-performance liquid chromatographic methods were developed for the quantitation of morin and quercetin in serum. The method employed a Cosmosil RP-18 column, using acetonitrile/0.2% o-phosphoric acid: 28/72 and 27/73 (v/v) as mobile phases, with ethyl paraben and 6,7-dimethoxycoumarin used as internal standards for morin and quercetin, respectively. Moreover, a strategy to stabilize morin/quercetin released from their glucuronides/sulfates in serum during hydrolysis was established. The present methods are applicable for determining morin, quercetin, and their glucuronides/sulfates in serum.

引用

页码：967 / 969

页数：3

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