Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine

被引：24

作者：

Correia, Maria Joao ^{[1
]}

Pimpao, Antonio B. ^{[1
]}

Fernandes, Dalila G. F. ^{[2
]}

Morello, Judit ^{[1
]}

Sequeira, Catarina O. ^{[1
]}

Calado, Joaquim ^{[3
,4
]}

Antunes, Alexandra M. M. ^{[5
]}

Almeida, Manuel S. ^{[1
,6
]}

Branco, Patricia ^{[1
,6
]}

Monteiro, Emilia C. ^{[1
]}

Vicente, Joao B. ^{[2
]}

Serpa, Jacinta ^{[1
,7
]}

Pereira, Sofia A. ^{[1
]}

机构：

[1] Univ Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal

[2] Inst Tecnol Quim & Biol Antonio Xavier ITQB NOVA, P-2780157 Oeiras, Portugal

[3] Univ Nova Lisboa, Fac Ciencias Med, Nova Med Sch, Ctr Toxicogen & Human Hlth ToxOm Genet Oncol & Hu, P-1169056 Lisbon, Portugal

[4] Ctr Hosp Univ Lisboa Cent, Dept Nephrol, P-1069166 Lisbon, Portugal

[5] Inst Super Tecn, Inst Mol Sci, Ctr Quim Estrut, P-1049001 Lisbon, Portugal

[6] Hosp Santa Cruz, Ctr Hosp Lisboa Ocidental, P-2790134 Carnaxide, Portugal

[7] Inst Portugues Oncol Lisboa Francisco Gentil IPOL, P-1099023 Lisbon, Portugal

来源：

MOLECULES | 2022年 / 27卷 / 04期

关键词：

cysteine-related thiolome; cysteine transporters; hypoxia; hypertension; kidney metabolism; glutathione; H2S; bioenergetics; ferroptosis; lysosomes; PENTOSE-PHOSPHATE PATHWAY; GAMMA-GLUTAMYL-TRANSPEPTIDASE; HYDROGEN-SULFIDE; OXIDATIVE STRESS; PROXIMAL TUBULE; AMINO-ACIDS; GLUTATHIONE METABOLISM; THIOL/DISULFIDE REDOX; INDUCED HYPERTENSION; TRANSCRIPTION FACTOR;

D O I：

10.3390/molecules27041416

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this review encouraged by original data, we first provided in vivo evidence that the kidney, comparative to the liver or brain, is an organ particularly rich in cysteine. In the kidney, the total availability of cysteine was higher in cortex tissue than in the medulla and distributed in free reduced, free oxidized and protein-bound fractions (in descending order). Next, we provided a comprehensive integrated review on the evidence that supports the reliance on cysteine of the kidney beyond cysteine antioxidant properties, highlighting the relevance of cysteine and its renal metabolism in the control of cysteine excess in the body as a pivotal source of metabolites to kidney biomass and bioenergetics and a promoter of adaptive responses to stressors. This view might translate into novel perspectives on the mechanisms of kidney function and blood pressure regulation and on clinical implications of the cysteine-related thiolome as a tool in precision medicine.

引用

页数：26

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