Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans

被引：0
|
作者：
Luciani, Genna M. [1 ,2 ]
Magomedova, Lilia [3 ]
Puckrin, Rachel [2 ]
Urbanus, Malene L. [2 ,4 ]
Wallace, Iain M. [2 ,4 ]
Giaever, Guri [1 ,2 ,3 ]
Nislow, Corey [1 ,2 ,4 ]
Cummins, Carolyn L. [3 ]
Roy, Peter J. [1 ,2 ]
机构：
[1] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada
[2] Univ Toronto, Donnelly Ctr Cellular & Biomol Res, Toronto, ON, Canada
[3] Univ Toronto, Dept Pharmaceut Sci, Toronto, ON, Canada
[4] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON, Canada
来源：
NATURE CHEMICAL BIOLOGY | 2011年 / 7卷 / 12期
基金：
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词：
LIFE-SPAN; LARVAL DEVELOPMENT; DEVELOPMENTAL AGE; NUCLEAR RECEPTOR; ENCODES; GENE; METABOLISM; DIAPAUSE;
D O I：
10.1038/NCHEMBIO.698
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematode Caenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals.
引用
收藏
页码：891 / 893
页数：3
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