An immunological method for the detection of BCR-ABL fusion protein and monitoring its activation
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作者:
Jilani, Iman
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Quest Diagnost Nichols Inst, Dept Hematol, San Juan Capistrano, CA 92690 USAQuest Diagnost Nichols Inst, Dept Hematol, San Juan Capistrano, CA 92690 USA
Jilani, Iman
[1
]
Kantarjian, Hagop
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Univ Texas Houston, MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USAQuest Diagnost Nichols Inst, Dept Hematol, San Juan Capistrano, CA 92690 USA
Kantarjian, Hagop
[2
]
Faraji, Homan
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Quest Diagnost Nichols Inst, Dept Hematol, San Juan Capistrano, CA 92690 USAQuest Diagnost Nichols Inst, Dept Hematol, San Juan Capistrano, CA 92690 USA
Faraji, Homan
[1
]
Gorre, Mercedes
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Quest Diagnost Nichols Inst, Dept Hematol, San Juan Capistrano, CA 92690 USAQuest Diagnost Nichols Inst, Dept Hematol, San Juan Capistrano, CA 92690 USA
Gorre, Mercedes
[1
]
Cortes, Jorge
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Univ Texas Houston, MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USAQuest Diagnost Nichols Inst, Dept Hematol, San Juan Capistrano, CA 92690 USA
Cortes, Jorge
[2
]
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Ottmann, Oliver
[3
]
Bhalla, Kapil
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HL Moffitt Canc Ctr, Dept Leukemia, Tampa, FL 33612 USAQuest Diagnost Nichols Inst, Dept Hematol, San Juan Capistrano, CA 92690 USA
Bhalla, Kapil
[4
]
O'Brien, Susan
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Univ Texas Houston, MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USAQuest Diagnost Nichols Inst, Dept Hematol, San Juan Capistrano, CA 92690 USA
O'Brien, Susan
[2
]
Giles, Francis
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Univ Texas Houston, MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USAQuest Diagnost Nichols Inst, Dept Hematol, San Juan Capistrano, CA 92690 USA
Giles, Francis
[2
]
Albitar, Maher
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Quest Diagnost Nichols Inst, Dept Hematol, San Juan Capistrano, CA 92690 USAQuest Diagnost Nichols Inst, Dept Hematol, San Juan Capistrano, CA 92690 USA
Albitar, Maher
[1
]
机构:
[1] Quest Diagnost Nichols Inst, Dept Hematol, San Juan Capistrano, CA 92690 USA
[2] Univ Texas Houston, MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA
We have developed a simplified sandwich immunoassay to measure free circulating total and phosphorylated fusion BCR-ABL protein in patients with the t(9;22)(q34;q11) chromosomal translocation. The assay is based on immunoprecipitating BCR-ABL protein using beads coated with anti-BCR antibody and detecting the fusion protein with anti-ABL antibody and flow cytometry. We show that this method allows the quantification of this protein in the plasma and may allow the measurement of tumor load. This method also allows the measurement of the level of phosphorylation of the immunoprecipitated BCR-ABL using antibodies against phosphorylated ABL protein, which can be used for monitoring of therapy with kinase inhibitors. The sensitivity of this immunoassay was comparable to the sensitivity of reverse transcription-polymerase chain reaction (RT-PCR) assay. This technique is useful in monitoring patients with chronic myeloid leukemia (CML) or acute lymphoblastic leukemia (ALL), but the same approach can be used in other translocations and has the potential of multiplexing. (c) 2007 Elsevier Ltd. All rights reserved.
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Quest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Ma, Wanlong
Tseng, Richard
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Quest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Tseng, Richard
Gorre, Mercedes
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Quest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Gorre, Mercedes
Jilani, Iman
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Quest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Jilani, Iman
Keating, Michael
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Univ Texas Houston, MD Anderson Canc Ctr, Leukemia Dept, Houston, TX 77030 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Keating, Michael
Kantarjian, Hagop
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Univ Texas Houston, MD Anderson Canc Ctr, Leukemia Dept, Houston, TX 77030 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Kantarjian, Hagop
Cortes, Jorge
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Univ Texas Houston, MD Anderson Canc Ctr, Leukemia Dept, Houston, TX 77030 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Cortes, Jorge
O'Brien, Susan
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Univ Texas Houston, MD Anderson Canc Ctr, Leukemia Dept, Houston, TX 77030 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
O'Brien, Susan
Giles, Francis
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Univ Texas Houston, MD Anderson Canc Ctr, Leukemia Dept, Houston, TX 77030 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Giles, Francis
Albitar, Maher
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机构:
Quest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
机构:
Quest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Ma, Wanlong
Tseng, Richard
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h-index: 0
机构:
Quest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Tseng, Richard
Gorre, Mercedes
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机构:
Quest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Gorre, Mercedes
Jilani, Iman
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机构:
Quest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Jilani, Iman
Keating, Michael
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机构:
Univ Texas Houston, MD Anderson Canc Ctr, Leukemia Dept, Houston, TX 77030 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Keating, Michael
Kantarjian, Hagop
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机构:
Univ Texas Houston, MD Anderson Canc Ctr, Leukemia Dept, Houston, TX 77030 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Kantarjian, Hagop
Cortes, Jorge
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机构:
Univ Texas Houston, MD Anderson Canc Ctr, Leukemia Dept, Houston, TX 77030 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Cortes, Jorge
O'Brien, Susan
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机构:
Univ Texas Houston, MD Anderson Canc Ctr, Leukemia Dept, Houston, TX 77030 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
O'Brien, Susan
Giles, Francis
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机构:
Univ Texas Houston, MD Anderson Canc Ctr, Leukemia Dept, Houston, TX 77030 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA
Giles, Francis
Albitar, Maher
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机构:
Quest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USAQuest Diagnost Nichols Inst, Hematopathol Dept, San Juan Capistrano, CA 92690 USA