One-step synthesis of polysubstituted benzene derivatives by multi-component cyclization of α-bromoacetate, malononitrile and aromatic aldehydes

被引：84

作者：

Yan, Chao Guo ^{[1
]}

Song, Xiao Kai ^{[1
]}

Wang, Qi Fang ^{[1
]}

Sun, Jing ^{[1
]}

Siemeling, Ulrich ^{[2
]}

Bruhn, Clemens ^{[2
]}

机构：

[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Peoples R China

[2] Univ Kassel, Inst Chem, D-34132 Kassel, Germany

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 12期

关键词：

D O I：

10.1039/b718171j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polysubstituted benzene derivatives with an unprecedented substitution pattern are produced in a novel one-pot multi-component cyclization reaction from pyridine, ethyl alpha-bromoacetate, malononitrile and aromatic aldehyde in refluxing acetonitrile.

引用

页码：1440 / 1442

页数：3

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