A comparison of the combination of epinephrine and vasopressin with lipid emulsion in a porcine model of asphyxial cardiac arrest after intravenous injection of bupivacaine

被引：87

作者：

Mayr, Viktoria D. ^{[1
]}

Mitterschiffthaler, Lukas ^{[1
]}

Neurauter, Andreas ^{[1
]}

Gritsch, Christian ^{[1
]}

Wenzel, Volker ^{[1
]}

Mueller, Tilko ^{[2
]}

Luckner, Guenter ^{[1
]}

Lindner, Karl H. ^{[1
]}

Strohmenger, Hans-Ulrich ^{[1
]}

机构：

[1] Innsbruck Med Univ, Dept Anesthesiol & Crit Care Med, A-6020 Innsbruck, Austria

[2] Innsbruck Med Univ, Dept Urol, A-6020 Innsbruck, Austria

来源：

ANESTHESIA AND ANALGESIA | 2008年 / 106卷 / 05期

关键词：

D O I：

10.1213/01.ane.0000278866.01963.79

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

BACKGROUND: In a porcine model, we compared the effect of the combination of vasopressin/epinephrine with that of a lipid emulsion on survival after bupivacaine-induced cardiac arrest. METHODS: After administration of 5 mg/kg of a 0.5% bupivacaine solution IV, ventilation was interrupted for 2 +/- 0.5 (mean +/- SD) min until asystole occurred. Cardiopulmonary resuscitation (CPR) was initiated after I min of untreated cardiac arrest. After 2 min of CPR, 10 animals received, every 5 min, either vasopressin combined with epinephrine or 4 mL/kg of a 20% lipid emulsion. Three minutes after each drug administration, up to three countershocks (4, 4, and 6 J/kg) were administered; all subsequent shocks with 6 J/kg. Blood for determination of the plasma bupivacaine concentration was drawn throughout the experiment. RESULTS: In the vasopressor group, all five pigs survived, whereas none of five pigs in the lipid group had restoration of spontaneous circulation (P < 0.01). There was no significant difference between groups in the plasma concentration of total bupivacaine. CONCLUSION: In this model of a bupivacaine-induced cardiac arrest, the vasopressor combination of vasopressin and epinephrine compared with lipid emulsion resulted in higher coronary perfusion pressure during CPR and survival rates.

引用

页码：1566 / 1571

页数：6

共 44 条

[41] Comparison between synchronized and non-synchronized ventilation and between guided and non-guided chest compressions during resuscitation in a pediatric animal model after asphyxial cardiac arrest [J].

Manrique, Gema ;

Garcia, Miriam ;

Fernandez, Sarah N. ;

Gonzalez, Rafael ;

Solana, Maria J. ;

Lopez, Jorge ;

Urbano, Javier ;

Lopez-Herce, Jesus .

PLOS ONE, 2019, 14 (07)

[42] Exposure to Stress-Dose Steroids and Lethal Septic Shock After In-Hospital Cardiac Arrest: Individual Patient Data Reanalysis of Two Prior Randomized Clinical Trials that Evaluated the Vasopressin-Steroids-Epinephrine Combination Versus Epinephrine Alone [J].

Mentzelopoulos, Spyros D. ;

Koliantzaki, Iosifina ;

Karvouniaris, Marios ;

Vrettou, Charikleia ;

Mongardon, Nicolas ;

Karlis, George ;

Makris, Demosthenes ;

Zakynthinos, Epaminondas ;

Sourlas, Sotirios ;

Aloizos, Stavros ;

Xanthos, Theodoros ;

Zakynthinos, Spyros G. .

CARDIOVASCULAR DRUGS AND THERAPY, 2018, 32 (04) :339-351

[43] Publisher Correction: Exposure to Stress-Dose Steroids and Lethal Septic Shock After In-Hospital Cardiac Arrest: Individual Patient Data Reanalysis of Two Prior Randomized Clinical Trials that Evaluated the Vasopressin–Steroids–Epinephrine Combination Versus Epinephrine Alone [J].

Spyros D. Mentzelopoulos ;

Iosifina Koliantzaki ;

Marios Karvouniaris ;

Charikleia Vrettou ;

Nicolas Mongardon ;

George Karlis ;

Demosthenes Makris ;

Epaminondas Zakynthinos ;

Sotirios Sourlas ;

Stavros Aloizos ;

Theodoros Xanthos ;

Spyros G. Zakynthinos .

Cardiovascular Drugs and Therapy, 2018, 32 :639-641

[44] Exposure to Stress-Dose Steroids and Lethal Septic Shock After In-Hospital Cardiac Arrest: Individual Patient Data Reanalysis of Two Prior Randomized Clinical Trials that Evaluated the Vasopressin-Steroids-Epinephrine Combination Versus Epinephrine Alone (vol 32, pg 339, 2018) [J].