Multimodal radio-(PET/SPECT) and fluorescence imaging agents based on metallo-radioisotopes: current applications and prospects for development of new agents

被引：93

作者：

Thorp-Greenwood, Flora L. ^{[1
]}

Coogan, Michael P. ^{[1
]}

机构：

[1] Cardiff Univ, Dept Chem, Cardiff CF10 3AT, Cymru, Wales

来源：

DALTON TRANSACTIONS | 2011年 / 40卷 / 23期

关键词：

MALEIMIDE BIFUNCTIONAL CHELATORS; POSITRON-EMISSION-TOMOGRAPHY; ZR-89; IMMUNO-PET; TC-99M COMPLEXES; BREAST-CANCER; IN-VITRO; BIS(THIOSEMICARBAZONATO) COMPLEXES; CONFOCAL FLUORESCENCE; MONOCLONAL-ANTIBODIES; ANTICANCER DRUGS;

D O I：

10.1039/c0dt01398f

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This perspective focuses on complexes of radioactive metal ions applied in multimodal radio- and optical imaging. The application of metal ions in radioimaging techniques such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) has advantages over lighter nuclei in terms of half-life, but there are particular issues related to their speciation (particularly leaching from complexes) and with the combination of certain ions with fluorescent systems. The basic coordination chemistry of the ions involved and issues relating to biological conditions and their compatibility with optical imaging techniques are reviewed, the current literature presented in context, and the prospect of exploiting the intrinsic luminescence of certain metal-ligand complexes is discussed.

引用

页码：6129 / 6143

页数：15

共 75 条

[1] Cell-specific and nuclear targeting with [M(CO)3]+ (M=99mTc, Re)-based complexes conjugated to acridine orange and bombesin [J].

Agorastos, Nikos ;

Borsig, Lubor ;

Renard, Anabelle ;

Antoni, Philipp ;

Viola, Giampietro ;

Spingler, Bernhard ;

Kurz, Philipp ;

Alberto, Roger .

CHEMISTRY-A EUROPEAN JOURNAL, 2007, 13 (14) :3842-3852

[2] Functionalised cyclopentadienyl zirconium compounds as potential anticancer drugs [J].

Allen, Olivia R. ;

Knox, Richard J. ;

McGowan, Patrick C. .

DALTON TRANSACTIONS, 2008, (39) :1293-1295

[3] Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs [J].

Allen, Olivia R. ;

Gott, Andrew L. ;

Hartley, John A. ;

Hartley, Janet M. ;

Knox, Richard J. ;

McGowan, Patrick C. .

DALTON TRANSACTIONS, 2007, (43) :5082-5090

[4] Differences between the macroscopic and tracer level chemistry of rhenium and technetium: contrasting cage isomerisation behaviour of Re(I) and Tc(I) carborane complexes [J].

Armstrong, Andrea F. ;

Valliant, John F. .

DALTON TRANSACTIONS, 2010, 39 (35) :8128-8131

[5] Functionalized Carborane Complexes of the [M(CO)2(NO)]2+ Core (M=99mTc, Re): A New Class of Organometallic Probes for Correlated in Vitro and in Vivo Imaging [J].

Armstrong, Andrea F. ;

Lebert, Julie M. ;

Brennan, John D. ;

Valliant, John F. .

ORGANOMETALLICS, 2009, 28 (10) :2986-2992

[6] Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes [J].

Backer, Marina V. ;

Levashova, Zoya ;

Patel, Vimalkumar ;

Jehning, Brian T. ;

Claffey, Kevin ;

Blankenberg, Francis G. ;

Backer, Joseph M. .

NATURE MEDICINE, 2007, 13 (04) :504-509

[7] The whole picture [J].

Baker, Monya .

NATURE, 2010, 463 (7283) :977-980

[8] Design and synthesis of site directed maleimide bifunctional chelators for technetium and rhenium [J].

Banerjee, SR ;

Schaffer, P ;

Babich, JW ;

Valliant, JF ;

Zubieta, J .

DALTON TRANSACTIONS, 2005, (24) :3886-3897

[9] Site directed maleimide bifunctional chelators for the M(CO)3+ core (M=99mTc, Re) [J].

Banerjee, SR ;

Babich, JW ;

Zubieta, J .

CHEMICAL COMMUNICATIONS, 2005, (13) :1784-1786

[10] Tricarbonyl Rhenium(I) and Technetium(I) Complexes with Hydrazones Derived from 4,5-Diazafluoren-9-one and 1,10-Phenanthroline-5,6-dione [J].

Barbazan, Paula ;

Hagenbach, Adelheid ;

Oehlke, Elisabeth ;

Abram, Ulrich ;

Carballo, Rosa ;

Rodriguez-Hermida, Sabina ;

Vazquez-Lopez, Ezequiel M. .

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2010, (29) :4622-4630

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