Intracellular heating of living cells through Neel relaxation of magnetic nanoparticles

被引：267
作者：
Fortin, Jean-Paul [1 ]
Gazeau, Florence [1 ]
Wilhelm, Claire [1 ]
机构：
[1] Univ Paris 07, CNRS, Lab Mat & Syst Complexes, UMR 7057, Paris, France
来源：
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS | 2008年 / 37卷 / 02期
关键词：
D O I：
10.1007/s00249-007-0197-4
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Maghemite and cobalt ferrite anionic magnetic nanoparticles enter tumor cells and can be used as heat sources when exposed to a high-frequency magnetic field. Comparative studies of the two particles enable to unravel the magnetic heating mechanisms (Neel relaxation vs. Brown relaxation) responsible for the cellular temperature rise, and also to establish a simple model, adjusted to the experimental results, allowing to predict the intracellular heating efficiency of iron oxide nanoparticles. Hence, we are able to derive the best nanoparticle design for a given material with a view to intracellular hyperthermia-based applications.
引用
收藏
页码：223 / 228
页数：6
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