Interaction of C60 Fullerene with the Proteins Involved in DNA Mismatch Repair Pathway

被引：20

作者：

Gupta, Shishir Kumar ^{[1
]}

Baweja, Lokesh ^{[1
]}

Gurbani, Deepak ^{[1
]}

Pandey, Alok K. ^{[1
]}

Dhawan, Alok ^{[1
]}

机构：

[1] CSIR, Indian Inst Toxicol Res, Nanomat Toxicol Grp, Lucknow 226001, Uttar Pradesh, India

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2011年 / 7卷 / 01期

关键词：

DNA Mismatch Repair; Homology Modeling; Fullerene; Docking;

D O I：

10.1166/jbn.2011.1258

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Fullerenes are fascinating symmetric carbon nanostructures with a potential to bind DNA and proteins. Computational studies were performed to investigate the interaction of fullerenes with the proteins involved in DNA mismatch repair (MMR) pathway. Significant interactions of fullerene with PMS2, RFC3 and PCNA proteins were observed. These findings suggested that fullerene interferes in the human MMR process hence the subsequent disturbance may confer a large increase in spontaneous mutability and a strong predisposition to tumor development.

引用

页码：179 / 180

页数：2

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