Placental expression of anti-angiogenic proteins in mirror syndrome: A case report

被引：19
作者：
Graham, N. [1 ]
Garrod, A. [2 ]
Bullen, P. [1 ]
Heazell, A. E. P. [1 ,2 ]
机构：
[1] Cent Manchester Univ Hosp Fdn Trust, St Marys Hosp, Dept Obstet & Gynaecol, Manchester M13 9WL, Lancs, England
[2] Univ Manchester, Maternal & Fetal Hlth Res Ctr, Manchester Acad Hlth Sci Ctr, Manchester M13 9PL, Lancs, England
来源：
PLACENTA | 2012年 / 33卷 / 06期
关键词：
Mirror syndrome; Ballantyne syndrome; Placental oedema; VEGF receptor 1; Endoglin; ANTIANGIOGENIC FACTORS; HYDROPS FETALIS;
D O I：
10.1016/j.placenta.2012.02.016
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Mirror syndrome is a rare disorder in which fetal hydrops is associated with maternal oedema, proteinuria and hypertension. The aetiology of the maternal condition is unknown, but it is thought to be related to preeclampsia. Few descriptions exist of placental morphology in mirror syndrome, but placentomegaly is consistently observed. In this case placental morphology showed villous oedema and syncytial nuclear aggregates where villi were in direct contact. Immunoperoxidase staining for VEGFR1 and Endoglin was more intense in mirror syndrome compared to gestational-age matched controls,and at a similar level to a case of preeclampsia. Placentally-derived anti-angiogenic factors may be involved in the pathogenesis of mirror syndrome. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：528 / 531
页数：4
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