GB virus C: the good boy virus?

被引：113
作者：
Bhattarai, Nirjal [1 ,2 ]
Stapleton, Jack T. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Iowa, Interdisciplinary Program Mol & Cellular Biol, Iowa City, IA 52242 USA
[2] Univ Iowa, Iowa City Vet Affairs Med Ctr, Iowa City, IA 52242 USA
[3] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA
[4] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA
来源：
TRENDS IN MICROBIOLOGY | 2012年 / 20卷 / 03期
基金：
美国国家卫生研究院;
关键词：
GBV-C; HIV; T cell; activation; IL-2; HEPATITIS-G VIRUS; HUMAN-IMMUNODEFICIENCY-VIRUS; PLASMACYTOID DENDRITIC CELLS; BLOOD MONONUCLEAR-CELLS; HIV-INFECTED PATIENTS; C/HEPATITIS-G VIRUS; T-LYMPHOCYTE; ANTIRETROVIRAL THERAPY; INTERLEUKIN-2; THERAPY; ENTRY INHIBITION;
D O I：
10.1016/j.tim.2012.01.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
GB virus C (GBV-C) is a lymphotropic human virus discovered in 1995 that is related to hepatitis C virus (HCV). GBV-C infection has not been convincingly associated with any disease; however, several studies found an association between persistent GBV-C infection and improved survival in HIV-positive individuals. GBV-C infection modestly alters T cell homeostasis in vivo through various mechanisms, including modulation of chemokine and cytokine release and receptor expression, and by diminution of T cell activation, proliferation and apoptosis, all of which may contribute to improved HIV clinical outcomes. In vitro studies confirm these clinical observations and demonstrate an anti-HIV replication effect of GBV-C. This review summarizes existing data on potential mechanisms by which GBV-C interferes with HIV, and the research needed to capitalize on this epidemiological observation.
引用
收藏
页码：124 / 130
页数：7
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