Distribution of HER2V655 genotypes in breast cancer cases and controls in the United States

被引：46

作者：

Keshava, C

McCanlies, EC

Keshava, N

Wolff, MS

Weston, A

机构：

[1] CDC, Toxicol & Mol Biol Branch, Hlth Effects Lab Div, NIOSH, Morgantown, WV 26505 USA

[2] CDC, Biostat Branch, Hlth Effects Lab Div, NIOSH, Morgantown, WV 26505 USA

[3] Mt Sinai Sch Med, New York, NY 10029 USA

来源：

CANCER LETTERS | 2001年 / 173卷 / 01期

关键词：

breast neoplasms; HER2; polymorphisms; African-Americans; Caucasians; Latinas;

D O I：

10.1016/S0304-3835(01)00671-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The minor variant frequency of a HER2 polymorphism (HER2(V655)) has been determined for 471 United States women enrolled in a multiracial case-control study. Allelic frequencies varied significantly by race. Genotypic distributions showed no excess breast cancer risk associated with inheritance of HER2(V655) either as carriers (OR = 1.2, 95% CI = 0.8-1.9), heterozygotes (OR = 1.2, 95% CI = 0.8-1.9), or homozygotes (OR = 1.4, 95% CI = 0.4-4.2). Nor was there a significant association when each racial group was considered separately. The current study suggests the HER2(V655) allele is not a breast cancer risk factor for Caucasians, African-Americans, or Latinas. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：37 / 41

页数：5

共 12 条

[1] Re: Population-based, case-control study of HER2 genetic polymorphism and breast cancer risk [J].