Influence of New III Class Antiarrhythmic Drug Niferidil (RG-2) on Bioelectrical Activity of Rat Pulmonary Veins Myocardium

被引：0
作者：
Egorov, Yu. V. [1 ]
Stolbova, V. I. [1 ]
Kuzmin, V. S. [1 ]
Rosenshtraukh, L. V. [1 ]
机构：
[1] Minist Hlth Care & Social Dev, Lab Electrophysiol Heart, Moscow 121552, Russia
来源：
KARDIOLOGIYA | 2012年 / 52卷 / 02期
关键词：
RG-2; niferidil; restitution; pulmonary vein; action potential; INTRAVENOUSLY ADMINISTERED DOFETILIDE; T-WAVE ALTERNANS; ATRIAL-FIBRILLATION; ACUTE TERMINATION; DOUBLE-BLIND; FLUTTER; EFFICACY; MULTICENTER; MECHANISMS; IBUTILIDE;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Myocardial cells in pulmonary veins are thought to play a major role in the initiation and maintenance of atrial arrhythmias, including atrial fibrillation. In experiments on rat pulmonary veins, antiarrhythmic drug niferidil (RG-2) produced increase of APD90% and functional refractory period and decrease of action potential amplitude and slope of APD restitution curve. Thus niferidil (RG-2) exerts stronger action on pulmonary veins than left atrium. This can take important part in Niferidil (RG-2) antiarrhythmic activity.
引用
收藏
页码：47 / 51
页数：5
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